File:Protease mechanism summary.svg

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File:Protease mechanism summary.svg - Wikipedia

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DescriptionProtease mechanism summary.svg	English: A comparison of the two mechanisms used for proteolysis. enzyme is shown in black, substrate protein in red and water in blue.The top panel shows 1-step hydrolysis where the enzyme uses an acid to polarise water which then hydrolyses the substrate. The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate. This forms an intermediate where the enzyme is covalently linked to the N-terminal half of the substrate. In a second step, water is activated to hydrolyse this intermediate and complete catalysis. Other enzyme residues (not shown) donate and accept hydrogens and electrostatically stabilise charge build-up along the reaction mechanism.
Date	22 August 2015
Source	Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge.
Author	Thomas Shafee

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	05:20, 22 August 2015		1,225 × 784 (529 KB)	Evolution and evolvability	User created page with UploadWizard

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Protease

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Usage on bs.wikipedia.org
- Proteaza
Usage on et.wikipedia.org
- Proteaasid
Usage on ja.wikipedia.org
- プロテアーゼ
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- User:Evolution and evolvability
Usage on zh.teknopedia.teknokrat.ac.id
- 蛋白酶

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Height	221.24834mm

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