From Wikipedia, the free encyclopedia
RNA family
HIF-1 alpha IRES | |
---|---|
![]() Predicted secondary structure and sequence conservation of IRES_HIF1 | |
Identifiers | |
Symbol | IRES_HIF1 |
Rfam | RF00449 |
Other data | |
RNA type | Cis-reg; IRES |
Domain(s) | Eukaryota |
GO | GO:0043022 |
SO | SO:0000243 |
PDB structures | PDBe |
The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap-independent translation. The HIF-1α internal ribosome entry site (IRES) allows translation to be maintained under hypoxic cell conditions that inhibit cap-dependent translation [1]. The hypoxia-inducible factor-1α protein (HIF-1α) is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response to hypoxia.
References
[edit]Further reading
[edit]- Lang KJ, Kappel A, Goodall GJ (May 2002). "Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia". Molecular Biology of the Cell. 13 (5): 1792–1801. doi:10.1091/mbc.02-02-0017. PMC 111144. PMID 12006670.
External links
[edit]![]() | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |
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