Interleukin-12 receptor

From Wikipedia, the free encyclopedia

interleukin 12 receptor, beta 1

Identifiers

Symbol

IL12RB1

Alt. symbols

IL12RB, CD212

Other data

Chr. 19 p13.1

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Structures	Swiss-model
Domains	InterPro

beta 2 subunit, interleukin 12 receptor, beta 2

Identifiers

Symbol

Other data

Chr. 1 p31.3-31.2

Search for
Structures	Swiss-model
Domains	InterPro

Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12 and consisting of beta 1^[1] and beta 2 subunits.^[2]

References

^ Chua AO, Chizzonite R, Desai BB, Truitt TP, Nunes P, Minetti LJ, Warrier RR, Presky DH, Levine JF, Gately MK (1994). "Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130". J. Immunol. 153 (1): 128–36. doi:10.4049/jimmunol.153.1.128. PMID 7911493. S2CID 9211163.
^ Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U (1996). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002–14007. Bibcode:1996PNAS...9314002P. doi:10.1073/pnas.93.24.14002. PMC 19484. PMID 8943050.

External links

Receptors,+Interleukin-12 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1 / CCRL1 CCR2 CCRL2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCR10
CXC	IL-8 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7
Other	CX3C CX3CR1 XC XCR1 CCBP2 CMKLR1

TNF receptor

1-10	TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) CD134 (TNFRSF4) CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8) CD137 (TNFRSF9)
11-20	DR4 (TNFRSF10A) DR5 (TNFRSF10B) DcR1 (TNFRSF10C) DcR2 (TNFRSF10D) RANK (TNFRSF11A) Osteoprotegerin (TNFRSF11B) TweakR (TNFRSF12A) TACI (TNFRSF13B) BAFFR (TNFRSF13C) HVEM (TNFRSF14) NGFR (TNFRSF16) BCMA (TNFRSF17) GITR (TNFRSF18) TAJ/TROY (TNFRSF19)
21-27	DR6 (TNFRSF21) DR3 (TNFRSF25) EDA2R (TNFRSF27)

JAK-STAT

Type I

γ-chain	Interleukin receptors IL2R / IL2RA/IL2RB / IL15R IL4R / IL13R / IL13RA1 / IL13RA2 IL7R / IL7RA IL9R IL21R
β-chain	Interleukin receptors IL3R / IL3RA IL5R / IL5RA GM-CSF
gp130	Interleukin receptors IL6RA 11/IL11RA 27/IL27RA OSMR LIFR CNTFR
IL12RB1	Interleukin receptors IL12R/IL12RB1/IL12RB2 IL23R
Other	other CSF receptors EPO G-CSF Thrombopoietin hormone receptor: GH prolactin

Type II

Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2

Ig superfamily

IL1
- IL1R1
- IL1R2
IL18R / IL18R1

IL 17 family

IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE

Enzyme-linked receptor

Tyr
- CSF1R
- KIT
Ser/Thr: TGF-beta
- TGFBR1
- TGFBR2
- family

Interleukin receptor modulators

IL-1

Decoy receptors: Rilonacept (IL-1 Trap)

IL-2

IL-3

IL-4

Antagonists: Pitrakinra

Antibodies: Dupilumab
Pascolizumab

IL-5

Agonists: Interleukin 5

Antagonists: YM-90709

Antisense oligonucleotides: TPI ASM8

IL-6

Agonists: Atexakin alfa
Interleukin 6

IL-7

Agonists: Interleukin 7

IL-8

See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.

IL-9

Agonists: Interleukin 9

Antibodies: Enokizumab

IL-10

Agonists: Ilodecakin
Interleukin 10 (CSIF)

IL-11

Agonists: Interleukin 11 (AGIF)
Oprelvekin

IL-12

Agonists: Edodekin alfa
Interleukin 12

Antibodies: Briakinumab
Ustekinumab

IL-13

IL-15

Agonists: ALT-803
Interleukin 15

IL-17

Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)

IL-18

Binding proteins: IL18BP

IL-20

Antibodies: Fletikumab (against IL-20)

IL-21

Agonists: Denenicokin
Interleukin 21

Antibodies: NNC0114-0005
NNC0114-0006

IL-22

Agonists: Interleukin 22

Antibodies: Fezakinumab (against IL-22)

IL-23

Agonists: Interleukin 23 (SGRF)

IL-27

Agonists: Interleukin 27 (interleukin 30)

IL-28

IL-31

Agonists: Interleukin 31

IL1RL1

Agonists: Interleukin 33

IL1RL2

Agonists: Interleukin 36 (α, β, γ)
Interleukin 38

Antagonists: IL-36RA

Others

JAK	See here instead.
Others	Interleukin 14 (taxilin alpha, HMW-BCGF) Interleukin 16 (signals through CD4) Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer) Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer) Interleukin 32 Interleukin 34 (signals through M-CSFR/CSF1R) Interleukin 35 Unsorted: Efavaleukin alfa Efineptakin alfa

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