From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
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Identifiers | |
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CAS Number | |
PubChem CID | |
Chemical and physical data | |
Formula | C22H28FN3O |
Molar mass | 369.484 g·mol−1 |
3D model (JSmol) | |
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TRV734 is a drug developed by Trevena Inc which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It is closely related to oliceridine and has a similar pharmacological profile, but unlike oliceridine which has to be injected, TRV734 is suitable to be administered orally.[1]
See also
[edit]References
[edit]- ^ James IE, Skobieranda F, Soergel DG, Ramos KA, Ruff D, Fossler MJ (February 2020). "A First-in-Human Clinical Study With TRV734, an Orally Bioavailable G-Protein-Biased Ligand at the μ-Opioid Receptor". Clinical Pharmacology in Drug Development. 9 (2): 256–266. doi:10.1002/cpdd.721. PMID 31286645. S2CID 195843184.
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