Ensiklopedia Dunia

From Wikipedia, the free encyclopedia

Timoprazole
Identifiers

IUPAC name 2-[(2-Pyridylmethyl)sulfinyl]-1H-benzimidazole
CAS Number	57237-97-5^Y
PubChem CID	72171
ChemSpider	65144^Y
UNII	95H6S1X9CC
KEGG	D05900
CompTox Dashboard (EPA)	DTXSID40866622
Chemical and physical data
Formula	C₁₃H₁₁N₃OS
Molar mass	257.31 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES n1ccccc1CS(=O)c2[nH]c3ccccc3n2
InChI InChI=1S/C13H11N3OS/c17-18(9-10-5-3-4-8-14-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,9H2,(H,15,16)^Y Key:HBDKFZNDMVLSHM-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Timoprazole is in a class of medications called proton pump inhibitors (PPI) that inhibit gastric acid secretion. While it has never come to market, it was studied early on and is considered to be the "backbone" of the PPI class that succeeded it.^[1]^[2] This medication has high anti-secretory activity, which flared interest along with its simple structure.^[3]

References

^ Snaeder W (1996). Drug prototypes and their exploitation. Wiley. pp. 414–5.
^ Hemenway JN (2007). "Case Study: Omeprazole (Prilosec)". Prodrugs. Biotechnology: Pharmaceutical Aspects. pp. 1313–21. doi:10.1007/978-0-387-49785-3_49. ISBN 978-0-387-49782-2.
^ Senn-Bilfinger J, Sturm E (2006). "The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole". Analogue-based Drug Discovery. pp. 115–36. doi:10.1002/3527608001.ch6. ISBN 978-3-527-60800-3.

v t e Drugs for peptic ulcer and GERD/GORD (A02B)
H₂ antagonists ("-tidine")	Cimetidine Famotidine Lafutidine Lavoltidine (loxtidine) Niperotidine Nizatidine Ranitidine^#‡ Roxatidine
Prostaglandins (E)/ analogues ("-prost-")	Misoprostol Enprostil
Proton-pump inhibitors ("-prazole")	Anaprazole Azeloprazole Dexlansoprazole Dexrabeprazole Esomeprazole Ilaprazole Lansoprazole Omeprazole^# Pantoprazole Picoprazole Rabeprazole Tenatoprazole Timoprazole
Potassium-competitive acid blockers ("-prazan")	Fexuprazan Linaprazan Revaprazan Soraprazan Tegoprazan Vonoprazan Zastaprazan
Others	Aceglutamide aluminum Acetoxolone Alginic acid Arbaclofen placarbil Bismuth subcitrate Carbenoxolone Cetraxate Gefarnate Irsogladine Lesogaberan Pirenzepine Proglumide Rebamipide Sucralfate Sulglicotide Telenzepine Teprenone Troxipide Zinc L-carnosine Zolimidine
Combinations	Bismuth subcitrate/metronidazole/tetracycline Omeprazole/amoxicillin/rifabutin Vonoprazan/amoxicillin Vonoprazan/amoxicillin/clarithromycin
See also: Helicobacter pylori* eradication protocols*
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

Categories:

Hidden categories: