Season 1880–81 was the fourth in which Hibernian competed at a Scottish national level, entering the Scottish Cup for the fourth time.

Hibs reached the third round of the Scottish Cup, losing 5–3 to Edinburgh derby rivals Hearts.^[1] The match was played in the Powderhall area of Edinburgh.^[1]

All results are written with Hibs' score first.

• List of Hibernian F.C. seasons

• Results For Season 1880/1881 in All Competitions, www.ihibs.co.uk

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