The 2021 All-Big 12 Conference football team consists of American football players chosen as All-Big 12 Conference players for the 2021 Big 12 Conference football season. The conference recognizes two official All-Big 12 selectors: (1) the Big 12 conference coaches selected separate offensive and defensive units and named first- and second-team players (the "Coaches" team); and (2) a panel of sports writers and broadcasters covering the Big 12 also selected offensive and defensive units and named first- and second-team players (the "Media" team).

• Spencer Sanders, Oklahoma State (Coaches-1)
• Brock Purdy, Iowa State (Coaches-2; Media-1)
• Caleb Williams, Oklahoma (Media-2)

• Breece Hall, Iowa State (Coaches-1; Media-1)
• Bijan Robinson, Texas (Coaches-1; Media-1)
• Abram Smith, Baylor (Coaches-2; Media-2)
• Deuce Vaughn, Kansas State (Coaches-2; Media-2)

• Jeremiah Hall, Oklahoma (Coaches-1)
• Jared Rus, Iowa State (Coaches-1)
• Jax Dineen, Kansas State (Coaches-2)

• Steve Avila, TCU (Coaches-2; Media-1)
• Collin Newell, Iowa State (Coaches-2)
• Jacob Gall, Baylor (Media-2)
• Dawson Deaton, Texas Tech (Coaches-2)
• Zach Frazier, West Virginia (Coaches-2)

• Josh Sills, Oklahoma State (Coaches-1; Media-1)
• Trevor Downing, Iowa State (Coaches-1; Media-1)
• Marquis Hayes, Oklahoma (Coaches-2; Media-2)
• Chris Murray, Oklahoma (Media-2)

• Cooper Beebe, Kansas State (Coaches-1; Media-1)
• Connor Galvin, Baylor (Coaches-1; Media-1)
• Derek Kerstetter, Texas (Coaches-1; Media-2)
• Tyrese Robinson, Oklahoma (Media-2)

• Charlie Kolar, Iowa State (Coaches-1; Media-1)
• Chase Allen, Iowa State (Coaches-2)
• Jeremiah Hall, Oklahoma (Media-2)

• Xavier Hutchinson, Iowa State (Coaches-1; Media-1)
• Xavier Worthy, Texas (Coaches-1; Media-1)
• Quentin Johnston, TCU (Coaches-1)
• Tay Martin, Oklahoma State (Coaches-2; Media-2)
• Tyquan Thornton, Baylor (Coaches-2; Media-2)
• Erik Ezukanma, Texas Tech (Coaches-2)

• Felix Anudike-Uzomah, Kansas State (Coaches-1; Media-1)
• Will McDonald IV, Iowa State (Coaches-1; Media-1)
• Dante Stills, West Virginia (Coaches-1; Media-1)
• Brock Martin, Oklahoma State (Coaches-1; Media-2)
• Eyioma Uwazurike, Iowa State (Coaches-1; Media-2)
• Siaki Ika, Baylor (Coaches-2; Media-1)
• Perrion Winfrey, Oklahoma (Coaches-2; Media-2)
• Collin Oliver, Oklahoma State (Coaches-2; Media-2)
• Kyron Johnson, Kansas (Coaches-2)
• Ochaun Mathis, TCU (Coaches-2)
• Isaiah Thomas, Oklahoma (Coaches-2)

• Terrel Bernard, Baylor (Coaches-1; Media-1)
• Malcolm Rodriguez, Oklahoma State (Coaches-1; Media-1)
• Mike Rose, Iowa State (Coaches-1; Media-1)
• Brian Asamoah, Oklahoma (Coaches-2; Media-2)
• Nik Bonitto, Oklahoma (Coaches-2; Media-2)
• Colin Schooler, Texas Tech (Coaches-2; Media-2)

• Jarrick Bernard-Converse, Oklahoma State (Coaches-1; Media-1)
• Kolby Harvell-Peel, Oklahoma State (Coaches-1; Media-1)
• Tre Tomlinson, TCU (Coaches-1; Media-1)
• Jalen Pitre, Baylor (Coaches-1; Media-1)
• Russ Yeast, Kansas State (Coaches-1; Media-2)
• DaMarcus Fields, Texas Tech (Coaches-2; Media-2)
• Christian Holmes, Oklahoma State (Coaches-2; Media-2)
• Kenny Logan Jr., Kansas (Coaches-2; Media-2)
• Delarrin Turner-Yell, Oklahoma (Coaches-2)
• Isheem Young, Iowa State (Coaches-2)

• Jonathan Garibay, Texas Tech (Coaches-1; Media-1)
• Gabe Brkic, Oklahoma (Coaches-2; Media-2)

• Michael Turk, Oklahoma (Coaches-1; Media-1)
• Cameron Dicker, Texas (Coaches-1)
• Austin McNamara, Texas Tech (Coaches-2; Media-2)

• Trestan Ebner, Baylor (Coaches-1; Media-1)
• Malik Knowles, Kansas State (Coaches-1; Media-2)
• Derius Davis, TCU (Coaches-2;
• Brennan Pressley, Oklahoma State (Coaches-2;

• 2021 College Football All-America Team