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ABI1 - Wikipedia

From Wikipedia, the free encyclopedia

ABI1

Identifiers

Aliases

ABI1, ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1

External IDs

OMIM: 603050; MGI: 104913; HomoloGene: 38053; GeneCards: ABI1; OMA:ABI1 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p12.1	Start	26,746,593 bp^[1]
Band	10p12.1	End	26,861,087 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 A3\|2 15.18 cM	Start	22,830,085 bp^[2]
Band	2 A3\|2 15.18 cM	End	22,930,253 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

epithelium of nasopharynx

amniotic fluid

palpebral conjunctiva

cartilage tissue

oral cavity

bronchial epithelial cell

skin of arm

bone marrow

thymus

mucosa of paranasal sinus

Top expressed in

mesenteric lymph nodes

subiculum

granulocyte

lateral septal nucleus

left lung lobe

parotid gland

lobe of cerebellum

skin of external ear

anterior amygdaloid area

ventral tegmental area

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein tyrosine kinase activator activity protein-containing complex binding cytoskeletal protein binding protein binding SH3 domain binding cadherin binding
Cellular component	cytoplasm cytosol postsynaptic membrane cell projection postsynaptic density SCAR complex membrane filopodium growth cone plasma membrane synapse intracellular anatomical structure cell junction cell leading edge endoplasmic reticulum neuron projection extracellular exosome cytoskeleton nucleus lamellipodium filopodium tip
Biological process	somitogenesis megakaryocyte development Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein tyrosine kinase activity vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine phosphorylation viral process lamellipodium morphogenesis negative regulation of cell population proliferation dendrite morphogenesis actin polymerization or depolymerization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10006


11308

Ensembl


ENSG00000136754


ENSMUSG00000058835

UniProt


Q8IZP0


Q8CBW3

RefSeq (mRNA)

NM_001012750 NM_001012751 NM_001012752 NM_001178116 NM_001178119
NM_001178120 NM_001178121 NM_001178122 NM_001178123 NM_001178124 NM_001178125 NM_005470 NM_001348029 NM_001348030 NM_001348031 NM_001348032 NM_001348033 NM_001348034

NM_001077190 NM_001077192 NM_001077193 NM_007380 NM_145994
NM_001331043 NM_001331044 NM_001331045 NM_001377510 NM_001377511 NM_001377512 NM_001377513

RefSeq (protein)

NP_001012768 NP_001012769 NP_001012770 NP_001171587 NP_001171590
NP_001171591 NP_001171592 NP_001171593 NP_001171594 NP_001171595 NP_001171596 NP_005461 NP_001334958 NP_001334959 NP_001334960 NP_001334961 NP_001334962 NP_001334963

NP_001070658 NP_001070660 NP_001070661 NP_001317972 NP_001317973
NP_001317974 NP_031406 NP_666106 NP_001364439 NP_001364440 NP_001364441 NP_001364442

Location (UCSC)

Chr 10: 26.75 – 26.86 Mb

Chr 2: 22.83 – 22.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene.^[5]^[6]

Function

Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene.^[7]

Abi1 is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 enhances the phosphorylation of WAVE2 by c-Abl. The phosphorylation of c-Abl promotes actin polymerization. Furthermore, Abi1 is a component of the WAVE complex. Some research has shown that knockdown of Abi1 by siRNA promoted degradation of WAVE complex proteins.^{[citation needed]}

Interactions

ABI1 has been shown to interact with

ENAH,^[8] NCKAP1,^[9] EPS8,^[6]^[8]^[9]^[10]^[11] and SOS1.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136754 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058835 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (Jul 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J Biol Chem. 273 (22): 13681–92. doi:10.1074/jbc.273.22.13681. PMID 9593709.
^ ^a ^b Biesova Z, Piccoli C, Wong WT (Feb 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.
^ "Entrez Gene: ABI1 abl-interactor 1".
^ ^a ^b Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
^ ^a ^b Yamamoto A, Suzuki T, Sakaki Y (June 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.
^ Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G (January 2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
^ Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (November 2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.
^ Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP (September 1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID 10499589. S2CID 205045006.

External links

ABI1 human gene location in the UCSC Genome Browser.
ABI1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

Categories:

Hidden categories:

Function

Interactions

References

Further reading

External links