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ALCAM - Wikipedia

From Wikipedia, the free encyclopedia

ALCAM

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
5A2F

Identifiers

Aliases

ALCAM, CD166, MEMD, activated leukocyte cell adhesion molecule

External IDs

OMIM: 601662; MGI: 1313266; HomoloGene: 1229; GeneCards: ALCAM; OMA:ALCAM - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q13.11	Start	105,366,909 bp^[1]
Band	3q13.11	End	105,576,900 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 B5	Start	52,069,359 bp^[2]
Band	16\|16 B5	End	52,274,437 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

mucosa of paranasal sinus

endothelial cell

palpebral conjunctiva

pars reticulata

corpus callosum

visceral pleura

external globus pallidus

pars compacta

trigeminal ganglion

Top expressed in

olfactory tubercle

vas deferens

right lung lobe

left lung lobe

stria vascularis

nucleus accumbens

anterior amygdaloid area

globus pallidus

ventromedial nucleus

lateral septal nucleus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding signaling receptor binding identical protein binding
Cellular component	integral component of membrane cell projection membrane focal adhesion intrinsic component of plasma membrane plasma membrane integral component of plasma membrane T cell receptor complex extracellular region axon soma dendrite immunological synapse extracellular exosome external side of plasma membrane
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules adaptive immune response immune system process neuron projection extension cell adhesion motor neuron axon guidance axon extension involved in axon guidance signal transduction retinal ganglion cell axon guidance axon guidance
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


214


11658

Ensembl


ENSG00000170017


ENSMUSG00000022636

UniProt


Q13740


Q61490

RefSeq (mRNA)


NM_001627 NM_001243280 NM_001243281 NM_001243283


NM_009655 NM_001331110

RefSeq (protein)


NP_001230209 NP_001230210 NP_001230212 NP_001618


NP_001318039 NP_033785

Location (UCSC)

Chr 3: 105.37 – 105.58 Mb

Chr 16: 52.07 – 52.27 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.^[5]^[6] It is also called CD166 (cluster of differentiation 166), MEMD,^[7] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands.^{[citation needed]} CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanom--a.^[7] CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.^{[citation needed]}

Recently, CD166 has also been used as a potential cancer stem cell marker.^{[citation needed]}

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170017 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022636 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.
^ "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule".
^ ^a ^b Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)". Am. J. Pathol. 152 (3): 805–13. PMC 1858405. PMID 9502422.

External links

ALCAM at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human ALCAM genome location and ALCAM gene details page in the UCSC Genome Browser.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Protein: scleroproteins

Extracellular
matrix

Collagen

Fibril forming	type I COL1A1 COL1A2 type II (COL2A1) type III type V COL5A1 COL5A2 COL5A3 COL24A1 COL26A1
Other	FACIT: type IX COL9A1 COL9A2 COL9A3 type XII (COL12A1) COL14A1 COL16A1 COL19A1 COL20A1 COL21A1 COL22A1 basement membrane: type IV COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 multiplexin: COL15A1 type XVIII COL18A1 Endostatin transmembrane: COL13A1 COL17A1 COL23A1 COL25A1 other: type VI COL6A1 COL6A2 COL6A3 COL6A5 type VII (COL7A1) type VIII COL8A1 COL8A2 type X (COL10A1) type XI COL11A1 COL11A2 COL27A1 COL28A1
Enzymes	Prolyl hydroxylase/Lysyl hydroxylase Cartilage associated protein/Leprecan ADAMTS2 Procollagen peptidase Lysyl oxidase