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ALG8 - Wikipedia

From Wikipedia, the free encyclopedia

ALG8

Identifiers

Aliases

ALG8, CDG1H, alpha-1,3-glucosyltransferase, PCLD3, ALG8 alpha-1,3-glucosyltransferase

External IDs

OMIM: 608103; MGI: 2141959; HomoloGene: 6931; GeneCards: ALG8; OMA:ALG8 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q14.1	Start	78,095,244 bp^[1]
Band	11q14.1	End	78,139,660 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E1	Start	97,020,813 bp^[2]
Band	7\|7 E1	End	97,041,392 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right testis

left testis

epithelium of colon

ventricular zone

testicle

right lobe of liver

right adrenal gland

left adrenal cortex

right adrenal cortex

stromal cell of endometrium

Top expressed in

tail of embryo

genital tubercle

spermatocyte

yolk sac

Paneth cell

otic vesicle

ventricular zone

endothelial cell of lymphatic vessel

zygote

spermatid

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	glycosyltransferase activity transferase activity hexosyltransferase activity alpha-1,3-mannosyltransferase activity dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity protein binding dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
Cellular component	integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane
Biological process	protein glycosylation dolichol-linked oligosaccharide biosynthetic process protein N-linked glycosylation oligosaccharide-lipid intermediate biosynthetic process mannosylation protein N-linked glycosylation via asparagine
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79053


381903

Ensembl


ENSG00000159063


ENSMUSG00000035704

UniProt


Q9BVK2


Q6P8H8

RefSeq (mRNA)


NM_001007027 NM_001007028 NM_024079


NM_199035

RefSeq (protein)


NP_001007028 NP_076984


NP_950200

Location (UCSC)

Chr 11: 78.1 – 78.14 Mb

Chr 7: 97.02 – 97.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase is an enzyme that in humans is encoded by the ALG8 gene.^[5]

This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159063 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035704 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ALG8 asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)".

External links

GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
Human ALG8 genome location and ALG8 gene details page in the UCSC Genome Browser.

Transferases: glycosyltransferases (EC 2.4)

2.4.1: Hexosyl-
transferases

Glucosyl-	Phosphorylase Starch Glycogen Cellobiose Myo- Glycogen synthase Debranching enzyme Branching enzyme 1,3-Beta-glucan synthase Ceramide glucosyltransferase N-glycosyltransferase
Galactosyl-	Lactose synthase B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1)
Glucuronosyl-	B3GAT1 B3GAT2 B3GAT3 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2A1 UGT2A2 UGT2A3 UGT2B4 UGT2B7 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 Hyaluronan synthase: HAS1 HAS2 HAS3
Fucosyl-	POFUT1 POFUT2 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 FUT10 FUT11
Mannosyl-	Dolichyl-phosphate-mannose-protein mannosyltransferase POMT1 POMT2 DPM1 DPM3 ALG1 ALG2 ALG3 ALG6 ALG8 ALG9 ALG12

2.4.2: Pentosyl-
transferases

Ribose

ADP-ribosyltransferase	NAD⁺:diphthamide ADP-ribosyltransferase Diphtheria toxin Pseudomonas exotoxin NAD(P)⁺:arginine ADP-ribosyltransferase Pertussis toxin Cholera toxin Poly ADP ribose polymerase Sirtuin
Phosphoribosyltransferase	Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Uracil phosphoribosyltransferase Amidophosphoribosyltransferase
Other	Purine nucleoside phosphorylase: Thymidine phosphorylase ECGF1

Other

2.4.99: Sialyl
transferases

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

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References

Further reading

External links