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ATP5G3 - Wikipedia

From Wikipedia, the free encyclopedia

ATP5MC3

Identifiers

Aliases

ATP5MC3, P3, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9), ATP synthase membrane subunit c locus 3, ATP5G3, DYTSPG

External IDs

OMIM: 602736; MGI: 2442035; HomoloGene: 133873; GeneCards: ATP5MC3; OMA:ATP5MC3 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q31.1	Start	175,176,258 bp^[1]
Band	2q31.1	End	175,181,710 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 C3	Start	73,738,791 bp^[2]
Band	2\|2 C3	End	73,741,670 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right ventricle

myocardium of left ventricle

body of tongue

renal medulla

Pons

apex of heart

vena cava

thoracic diaphragm

mucosa of transverse colon

atrium

Top expressed in

myocardium of ventricle

atrioventricular valve

endocardial cushion

right kidney

digastric muscle

extraocular muscle

thoracic diaphragm

cardiac muscles

renal corpuscle

deep cerebellar nuclei

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transporter activity proton transmembrane transporter activity lipid binding proton-transporting ATP synthase activity, rotational mechanism
Cellular component	integral component of membrane proton-transporting two-sector ATPase complex, proton-transporting domain mitochondrial proton-transporting ATP synthase complex membrane mitochondrial membranes mitochondrial outer membrane mitochondrion proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Biological process	ion transport ATP biosynthetic process ATP synthesis coupled proton transport cristae formation mitochondrial ATP synthesis coupled proton transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


518


228033

Ensembl


ENSG00000154518


ENSMUSG00000018770

UniProt


P48201


P56384

RefSeq (mRNA)


NM_001689 NM_001002258 NM_001190329 NM_001002256


NM_001301721 NM_001301722 NM_175015

RefSeq (protein)


NP_001002258 NP_001177258 NP_001680


NP_001288650 NP_001288651 NP_778180

Location (UCSC)

Chr 2: 175.18 – 175.18 Mb

Chr 2: 73.74 – 73.74 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

The ATP5MC3 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.^[5]^[6]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154518 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018770 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yan WL, Lerner TJ, Haines JL, Gusella JF (May 1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
^ ^a ^b "Entrez Gene: ATP synthase membrane subunit c locus 3".

External links

Human ATP5MC3 genome location and ATP5MC3 gene details page in the UCSC Genome Browser.

References

External links

Further reading