Acetate CoA-transferase

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acetate CoA-transferase

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In enzymology, an acetate CoA-transferase (EC 2.8.3.8) is an enzyme that catalyzes the chemical reaction

acyl-CoA + acetate

\rightleftharpoons

a fatty acid anion + acetyl-CoA

Thus, the two substrates of this enzyme are acyl-CoA and acetate, whereas its two products are long-chain carboxylate anion and acetyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acyl-CoA:acetate CoA-transferase. Other names in common use include acetate coenzyme A-transferase, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase, and succinyl-CoA:acetate CoA transferase.

This enzyme participates in 4 metabolic pathways:

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1K6D.

References

Vanderwinkel E, Furmanski P, Reeves HC, Ajl SJ (1968). "Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity". Biochem. Biophys. Res. Commun. 33 (6): 902–8. doi:10.1016/0006-291X(68)90397-5. PMID 4884054.
Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184 (1): 207–15. doi:10.1128/JB.184.1.207-215.2002. PMC 134768. PMID 11741862.
Gobel M, Kassel-Cati K, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184 (1): 216–23. doi:10.1128/JB.184.1.216-223.2002. PMC 134769. PMID 11741863.

External links

Media related to Acetato CoA-transferase at Wikimedia Commons

v t e Transferases: sulfur-containing group (EC 2.8)
2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase lipoyl synthase molybdenum cofactor sulfurtransferase thiazole synthase molybdopterin synthase sulfurtransferase molybdopterin synthase tRNA-uridine 2-sulfurtransferase () tRNA-5-taurinomethyluridine 2-sulfurtransferase () tRNA-5-methyluridine⁵⁴ 2-sulfurtransferase () L-aspartate semialdehyde sulfurtransferase ()
2.8.2: Sulfotransferases	aryl sulfotransferase amine sulfotransferase estrone sulfotransferase chondroitin 4-sulfotransferase choline sulfotransferase UDP-N-acetylgalactosamine-4-sulfate sulfotransferase heparan sulfate-glucosamine N-sulfotransferase tyrosine-ester sulfotransferase Renilla-luciferin sulfotransferase galactosylceramide sulfotransferase psychosine sulfotransferase bile salt sulfotransferase steroid sulfotransferase thiol sulfotransferase chondroitin 6-sulfotransferase cortisol sulfotransferase triglucosylalkylacylglycerol sulfotransferase protein-tyrosine sulfotransferase keratan sulfotransferase aryl-sulfate sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 1 desulfoglucosinolate sulfotransferase flavonol 3-sulfotransferase quercetin-3-sulfate 3′-sulfotransferase quercetin-3-sulfate 4′-sulfotransferase quercetin-3,3′-bissulfate 7-sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 2 (heparan sulfate)-glucosamine 3-sulfotransferase 3 petromyzonol sulfotransferase scymnol sulfotransferase N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase glycochenodeoxycholate sulfotransferase dermatan 4-sulfotransferase desulfo-A47934 sulfotransferase () trehalose 2-sulfotransferase () aliphatic desulfoglucosinolate sulfotransferase () hydroxyjasmonate sulfotransferase () ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase (*) Alcohol sulfotransferase Tyrosylprotein sulfotransferase
2.8.3: CoA-transferases	Propionate CoA-transferase oxalate CoA-transferase malonate CoA-transferase 3-oxoacid CoA-transferase 3-oxoadipate CoA-transferase succinyl-CoA—Dcitramalate CoA-transferase acetate CoA-transferase butyrate—acetoacetate CoA-transferase citrate CoA-transferase citramalate CoA-transferase glutaconate CoA-transferase succinate—hydroxymethylglutarate CoA-transferase 5-hydroxypentanoate CoA-transferase succinyl-CoA:(R)-benzylsuccinate CoA-transferase formyl-CoA transferase cinnamoyl-CoA:phenyllactate CoA-transferase succinyl-CoA:acetate CoA-transferase () CoA:oxalate CoA-transferase () succinyl-CoA—D-citramalate CoA-transferase () L-carnitine CoA-transferase () succinyl-CoA—L-malate CoA-transferase () caffeate CoA-transferase () (R)-2-hydroxy-4-methylpentanoate CoA-transferase () bile acid CoA-transferase () succinyl-CoA:mesaconate CoA transferase (*)
2.8.4: Alkylthio	2.8.4: Coenzyme-B sulfoethylthiotransferase arsenate-mycothiol transferase tRNA-2-methylthio-N⁶-dimethylallyladenosine synthase () [ribosomal protein S12] (aspartate⁸⁹-C³)-methylthiotransferase () tRNA (N⁶-L-threonylcarbamoyladenosine³⁷-C²)-methylthiotransferase (*)
2.8.5:	2.8.5: S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent) () L-cysteine S-thiosulfotransferase ()

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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