adipocyte protein 2

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FABP4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4NNT, 1TOU, 1TOW, 2HNX, 2NNQ, 3FR2, 3FR4, 3FR5, 3P6C, 3P6D, 3P6E, 3P6F, 3P6G, 3P6H, 3Q6L, 3RZY, 4NNS, 5EDB, 5EDC, 5D48, 5D4A, 5D45, 5D47

Identifiers

Aliases

FABP4, A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid binding protein 4

External IDs

OMIM: 600434; MGI: 88038; HomoloGene: 36067; GeneCards: FABP4; OMA:FABP4 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q21.13	Start	81,478,419 bp^[1]
Band	8q21.13	End	81,483,236 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 A1\|3 2.56 cM	Start	10,269,148 bp^[2]
Band	3 A1\|3 2.56 cM	End	10,273,636 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

abdominal fat

pericardium

skin of hip

subcutaneous adipose tissue

vena cava

lactiferous duct

synovial joint

trabecular bone

gastric mucosa

thoracic diaphragm

Top expressed in

intercostal muscle

tunica adventitia of aorta

transitional epithelium of urinary bladder

brown adipose tissue

tunica media of zone of aorta

parotid gland

decidua

gastrula

aortic valve

ascending aorta

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transporter activity fatty acid binding lipid binding long-chain fatty acid transporter activity long-chain fatty acid binding hormone receptor binding
Cellular component	cytosol lipid droplet extracellular exosome nucleus cytoplasm
Biological process	white fat cell differentiation regulation of inflammatory response cytokine production cholesterol homeostasis positive regulation of inflammatory response negative regulation of transcription, DNA-templated cellular response to lithium ion negative regulation of protein kinase activity brown fat cell differentiation triglyceride catabolic process cellular response to tumor necrosis factor transport response to bacterium long-chain fatty acid transport positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2167


11770

Ensembl


ENSG00000170323


ENSMUSG00000062515

UniProt


P15090


P04117

RefSeq (mRNA)


NM_001442


NM_024406

RefSeq (protein)


NP_001433


NP_077717

Location (UCSC)

Chr 8: 81.48 – 81.48 Mb

Chr 3: 10.27 – 10.27 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

aP2 (adipocyte Protein 2)^[5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs^[6] has the possibility of treating heart disease and the metabolic syndrome.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170323 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062515 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry. 28 (22): 8683–90. doi:10.1021/bi00448a003. PMID 2481498.
^ Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A (September 2017). "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry. 138: 854–873. doi:10.1016/j.ejmech.2017.07.022. PMID 28738306.
^ Furuhashi M (March 2019). "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Review. Journal of Atherosclerosis and Thrombosis. 26 (3): 216–232. doi:10.5551/jat.48710. PMC 6402888. PMID 30726793.

External links

FABP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte
PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte

v t e Proteins: carrier proteins
Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7
Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin
Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor
Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin
Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin
Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

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References

External links