Bone morphogenetic protein 5

Technopedia Center

Faculty of Engineering and Computer Science
S1 Informatics S1 Information Systems S1 Information Technology S1 Computer Engineering S1 Electrical Engineering S1 Civil Engineering

faculty of Economics and Business
S1 Management S1 Accountancy

Faculty of Letters and Educational Sciences
S1 English literature S1 English language education S1 Mathematics education S1 Sports Education

Bone morphogenetic protein 5 - Wikipedia

From Wikipedia, the free encyclopedia

BMP5

Identifiers

Aliases

BMP5, entrez:653, bone morphogenetic protein 5

External IDs

OMIM: 112265; MGI: 88181; HomoloGene: 22412; GeneCards: BMP5; OMA:BMP5 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p12.1	Start	55,753,653 bp^[1]
Band	6p12.1	End	55,875,590 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 D\|9 42.34 cM	Start	75,682,646 bp^[2]
Band	9 D\|9 42.34 cM	End	75,807,592 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

islet of Langerhans

cartilage tissue

tibia

placenta

Epithelium of choroid plexus

mucosa of urinary bladder

rectum

jejunal mucosa

right lung

Top expressed in

secondary oocyte

zygote

primary oocyte

vestibular sensory epithelium

left lung lobe

vestibular membrane of cochlear duct

Paneth cell

skin of external ear

carotid body

right lung

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cytokine activity BMP receptor binding transforming growth factor beta receptor binding growth factor activity
Cellular component	extracellular region extracellular space vesicle cellular component
Biological process	regulation of apoptotic process pattern specification process skeletal system development cell differentiation male genitalia development regulation of MAPK cascade SMAD protein signal transduction ossification positive regulation of epithelial cell proliferation negative regulation of mononuclear cell migration negative regulation of cortisol biosynthetic process positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of dendrite development BMP signaling pathway multicellular organism development cartilage development negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of insulin-like growth factor receptor signaling pathway type B pancreatic cell development negative regulation of steroid biosynthetic process negative regulation of epithelial to mesenchymal transition positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation negative regulation of aldosterone biosynthetic process endocardial cushion formation pericardium morphogenesis neural fold elevation formation hindbrain development cardiac muscle tissue development pharyngeal system development cardiac septum morphogenesis chorio-allantoic fusion heart trabecula morphogenesis allantois development regulation of signaling receptor activity ear development anterior head development positive regulation of cell population proliferation cell development signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


653


12160

Ensembl


ENSG00000112175


ENSMUSG00000032179

UniProt


P22003


P49003

RefSeq (mRNA)


NM_021073 NM_001329754 NM_001329756


NM_007555

RefSeq (protein)


NP_001316683 NP_001316685 NP_066551 NP_066551.1


NP_031581

Location (UCSC)

Chr 6: 55.75 – 55.88 Mb

Chr 9: 75.68 – 75.81 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.^[5]^[6]^[7]

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112175 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032179 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
^ Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience. 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864.
^ ^a ^b "Entrez Gene: BMP5 bone morphogenetic protein 5".

External links

Human BMP5 genome location and BMP5 gene details page in the UCSC Genome Browser.

Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (Dec 1990). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proceedings of the National Academy of Sciences of the United States of America. 87 (24): 9843–7. Bibcode:1990PNAS...87.9843C. doi:10.1073/pnas.87.24.9843. PMC 55270. PMID 2263636.
Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S (Apr 1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochemical and Biophysical Research Communications. 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID 8630036.
You L, Kruse FE, Pohl J, Völcker HE (Feb 1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Investigative Ophthalmology & Visual Science. 40 (2): 296–311. PMID 9950587.
Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S (Aug 2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathology International. 51 (8): 643–8. doi:10.1046/j.1440-1827.2001.01243.x. PMID 11564221. S2CID 35052100.
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (Oct 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G (Jan 2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". American Journal of Medical Genetics. 107 (1): 48–51. doi:10.1002/ajmg.10083. PMID 11807867.
Jiang FX, Stanley EG, Gonez LJ, Harrison LC (Feb 2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". Journal of Cell Science. 115 (Pt 4): 753–60. doi:10.1242/jcs.115.4.753. PMID 11865031.
Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W (May 2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". The Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953. S2CID 42730702.
Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF (Jul 2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Molecular Vision. 8: 241–50. PMID 12131877.
Nakayama N, Han CY, Cam L, Lee JI, Pretorius J, Fisher S, Rosenfeld R, Scully S, Nishinakamura R, Duryea D, Van G, Bolon B, Yokota T, Zhang K (Jan 2004). "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development. 131 (1): 229–40. doi:10.1242/dev.00901. PMID 14660436.
Xu WP, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, Kurihara H (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biology International. 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325. S2CID 45261710.
Bobinac D, Marić I, Zoricić S, Spanjol J, Dordević G, Mustać E, Fuckar Z (Jun 2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croatian Medical Journal. 46 (3): 389–96. PMID 15861517.
Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR (2006). "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Research & Therapy. 8 (3): R58. doi:10.1186/ar1923. PMC 1526630. PMID 16542506.
Wilkins JM, Southam L, Price AJ, Mustafa Z, Carr A, Loughlin J (Mar 2007). "Extreme context specificity in differential allelic expression". Human Molecular Genetics. 16 (5): 537–46. doi:10.1093/hmg/ddl488. PMID 17220169.

Cell signaling: TGFβ signaling pathway

TGF beta superfamily of ligands

Ligand of ACVR or TGFBR	TGF beta family TGF-β1 TGF-β2 TGF-β3 Activin and inhibin INHA INHBA INHBB INHBC Nodal
Ligand of BMPR	Bone morphogenetic proteins BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8a BMP8b BMP10 BMP15 Growth differentiation factors GDF1 GDF2 GDF3 GDF5 GDF6 GDF7 Myostatin/GDF8 GDF9 GDF10 GDF11 GDF15 Anti-müllerian hormone

TGF beta receptors
(Activin, BMP, family)

TGFBR1:	Activin type 1 receptors ACVR1 ACVR1B ACVR1C ACVRL1 BMPR1 BMPR1A BMPR1B
TGFBR2:	Activin type 2 receptors ACVR2A ACVR2B AMHR2 BMPR2
TGFBR3:	betaglycan

Transducers/SMAD

Ligand inhibitors

Coreceptors

BAMBI
Cripto

Other

SARA

TGFβ receptor superfamily modulators

Type I

ALK1 (ACVRL1)	Agonists: Activin (A, B, AB) Avotermin BMP (10) Cetermin GDF (2 (BMP9)) TGFβ (1, 2, 3) Antibodies: Ascrinvacumab Kinase inhibitors: K-02288 ML-347 (LDN-193719, VU0469381) Decoy receptors: Dalantercept Other inhibitors: Disitertide
ALK2 (ACVR1A)	Agonists: Activin (A, B, AB) AMH (MIS) Avotermin BMP (5, 6, 7, 8A, 8B) Eptotermin alfa TGFβ (1, 2, 3) Kinase inhibitors: DMH-1 DMH-2 Dorsomorphin (BML-275) K-02288 ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)	Agonists: AMH (MIS) BMP (2, 4, 5, 6, 7, 8A, 8B) Dibotermin alfa Eptotermin alfa Kinase inhibitors: DMH-2 Dorsomorphin (BML-275) K-02288
ALK4 (ACVR1B)	Agonists: Activin (A, B, AB) GDF (1, 3, 11 (BMP11)) Myostatin (GDF8) Nodal Antagonists: Inhibin (A, B) Lefty (1, 2) Kinase inhibitors: A 83-01 SB-431542 SB-505124
ALK5 (TGFβR1)	Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388 LY-364947 LY-2109761 Galunisertib (LY-2157299) R-268712 RepSox (E-616452, SJN-2511) SB-431542 SB-505124 SB-525334 SD-208
ALK6 (BMPR1B)	Agonists: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15) Radotermin Kinase inhibitors: DMH-2 Dorsomorphin (BML-275) K-02288
ALK7 (ACVR1C)	Agonists: GDF (1, 3, 11 (BMP11)) Nodal Antagonists: Lefty (1, 2) Kinase inhibitors: A 83-01 SB-431542 SB-505124

Type II

TGFβR2	Agonists: Avotermin GDF (10 (BMP3B)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947
BMPR2	Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12)) Radotermin Antagonists: Inhibin (A, B)
ACVR2A (ACVR2)	Agonists: Activin (A, B, AB) BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15) Myostatin (GDF8) Nodal Radotermin Antagonists: Inhibin (A, B) Lefty (1, 2) Decoy receptors: Sotatercept
ACVR2B	Agonists: Activin (A, B, AB) BMP (2, 4, 6, 7) Dibotermin alfa Eptotermin alfa GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12)) Myostatin (GDF8) Nodal Osteogenin (BMP3, BMP3A) Radotermin Antagonists: Inhibin (A, B) Lefty (1, 2) Decoy receptors: Ramatercept
AMHR2 (AMHR)	Agonists: AMH (MIS)

Type III

TGFβR3 (β-glycan)	Ligands: Avotermin Inhibin (A, B) TGFβ (1, 2, 3)

Unsorted

Endogenous antagonists/inhibitors: BAMBI
Cerberus (CER1)
Chordin
DAN (PARN)
Decorin
Follistatin
Gremlin (Drm)
LTBP1
Noggin
TGIF
Thrombospondin 1 (THBS1)
Tomoregulin 1

Antibodies: Stamulumab (against myostatin)
TRC105 (against endoglin)

Others: Endoglin

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Categories:

Hidden categories:

References

External links

Further reading