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CD24 - Wikipedia

From Wikipedia, the free encyclopedia

CD24

Identifiers

Aliases

CD24, CD24A, CD24 molecule

External IDs

OMIM: 600074; MGI: 88323; GeneCards: CD24; OMA:CD24 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q21	Start	106,969,831 bp^[1]
Band	6q21	End	106,975,627 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 B2\|10 23.01 cM	Start	43,454,280 bp^[2]
Band	10 B2\|10 23.01 cM	End	43,460,261 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

renal medulla

bronchial epithelial cell

mucosa of colon

mucosa of sigmoid colon

oral cavity

parotid gland

gingival epithelium

epithelium of nasopharynx

mucosa of ileum

pancreatic epithelial cell

Top expressed in

fetal liver hematopoietic progenitor cell

crypt of lieberkuhn of small intestine

superior cervical ganglion

epithelium of stomach

human fetus

medial ganglionic eminence

epithelium of lens

parotid gland

tibiofemoral joint

blood

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein tyrosine kinase activator activity signal transducer activity protein binding protein kinase binding
Cellular component	membrane plasma membrane cell surface anchored component of external side of plasma membrane membrane raft anchored component of membrane intracellular anatomical structure
Biological process	response to hypoxia regulation of MAPK cascade positive regulation of MAP kinase activity regulation of cytokine-mediated signaling pathway positive regulation of cytosolic calcium ion concentration chemokine receptor transport out of membrane raft T cell costimulation regulation of phosphorylation Wnt signaling pathway negative regulation of transforming growth factor beta3 production cell activation immune response-regulating cell surface receptor signaling pathway response to estrogen respiratory burst intrinsic apoptotic signaling pathway glomerular parietal epithelial cell differentiation cell adhesion glomerular visceral epithelial cell differentiation cholesterol homeostasis regulation of epithelial cell differentiation response to molecule of bacterial origin cell migration B cell receptor transport into membrane raft positive regulation of nephron tubule epithelial cell differentiation positive regulation of activated T cell proliferation positive regulation of protein tyrosine kinase activity cell-cell adhesion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


100133941


12484

Ensembl


ENSG00000272398


ENSMUSG00000047139

UniProt


P25063


P24807

RefSeq (mRNA)


NM_001291737 NM_001291738 NM_001291739 NM_013230 NM_001359084


NM_009846

RefSeq (protein)


NP_001278666 NP_001278667 NP_001278668 NP_037362 NP_001346013


NP_033976

Location (UCSC)

Chr 6: 106.97 – 106.98 Mb

Chr 10: 43.45 – 43.46 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.^[5] CD24 is a cell adhesion molecule.

Function

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils^[6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.^[7] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,^[8] and this appears to be defective in sepsis.^[8] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.^{[citation needed]}

Researchers have identified CD24 as a novel cell surface marker that flags anastasis in melanoma cells, a process where cells that have initiated apoptosis can recover and survive.^[9] This discovery highlights CD24’s role in marking apoptotic subpopulations that exhibit metabolic activity and proliferative capacities, contributing to melanoma’s resilience and potential metastasis.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000272398 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047139 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics. 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762.
^ Elghetany MT, Patel J (December 2002). "Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development". American Journal of Hematology. 71 (4): 348–9. doi:10.1002/ajh.10176. PMID 12447971. S2CID 39674808.
^ Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural development and disease". Neurobiology of Disease. 99: 133–144. doi:10.1016/j.nbd.2016.12.011. PMID 27993646. S2CID 3492300.
^ ^a ^b Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon JM (March 2014). "CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis". Journal of Immunology. 192 (5): 2449–59. doi:10.4049/jimmunol.1301055. PMID 24501201. S2CID 45838206.
^ Vasileva MH, Bennemann A, Zachmann K, Schön MP, Frank J, Ulaganathan VK (August 2024). "CD24 flags anastasis in melanoma cells". Apoptosis. doi:10.1007/s10495-024-01990-1. PMID 39136818.

External links

CD24+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart
www.copewithcytokines.de: description of CD24 expression
CD24 human gene location in the UCSC Genome Browser.
CD24 human gene details in the UCSC Genome Browser.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Membrane proteins: cell adhesion molecules

Calcium-independent

IgSF CAM	N-CAM (Myelin protein zero) ICAM (1, 5) VCAM-1 PE-CAM L1 family L1-CAM NRCAM NFASC CHL1 Nectin PVRL1 PVRL2 PVRL3 CADM1 CADM3 CD155
Integrins	LFA-1 (CD11a+CD18) Integrin alphaXbeta2 (CD11c+CD18) Macrophage-1 antigen (CD11b+CD18) VLA-4 (CD49d+CD29) Glycoprotein IIb/IIIa (ITGA2B+ITGB3)

Calcium-dependent

Cadherins

Classical	CDH1 CDH2 CDH3
Desmosomal	Desmoglein (DSG1, DSG2, DSG3, DSG4) Desmocollin (DSC1, DSC2, DSC3)
Protocadherin	PCDH1 PCDH15 PCDH19
Unconventional/ungrouped	T-cadherin CDH4 CDH5 CDH6 CDH8 CDH11 CDH12 CDH15 CDH16 CDH17 CDH9 CDH10

Selectins

Other

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

Categories:

Hidden categories:

Function

References

Further reading

External links