CoA-glutathione reductase

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CoA-glutathione reductase

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In enzymology, a CoA-glutathione reductase (EC 1.8.1.10) is an enzyme that catalyzes the chemical reaction

CoA + glutathione + NADP⁺

\rightleftharpoons

CoA-glutathione + NADPH + H⁺

The 3 substrates of this enzyme are CoA, glutathione, and NADP⁺, whereas its 3 products are CoA-glutathione, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glutathione:NADP+ oxidoreductase (CoA-acylating). Other names in common use include coenzyme A glutathione disulfide reductase, NADPH-dependent coenzyme A-SS-glutathione reductase, coenzyme A disulfide-glutathione reductase, and NADPH:CoA-glutathione oxidoreductase. This enzyme participates in cysteine metabolism. It employs one cofactor, FAD.

References

Ondarza RN, Abney R, Lopez-Colome AM (1969). "Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast". Biochim. Biophys. Acta. 191 (2): 239–48. doi:10.1016/0005-2744(69)90243-5. PMID 4390951.
Ondarza RN, Escamilla E, Gutierrez J, De la Chica G (1974). "CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity". Biochim. Biophys. Acta. 341 (1): 162–71. doi:10.1016/0005-2744(74)90076-x. PMID 4151341.
Carlberg I, Mannervik B (1977). "Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione". Biochim. Biophys. Acta. 484 (2): 268–74. doi:10.1016/0005-2744(77)90083-3. PMID 334266.

v t e Oxidoreductases: sulfur oxidoreductases (EC 1.8)
1.8.1: NAD or NADP	Dihydrolipoamide dehydrogenase Glutathione reductase Thioredoxin reductase
1.8.2: cytochrome	Sulfite dehydrogenase Thiosulfate dehydrogenase Flavocytochrome c sulfide dehydrogenase
1.8.3: oxygen	Sulfite oxidase
1.8.4: disulfide	Glutathione—homocystine transhydrogenase
1.8.5: quinone	Glutathione dehydrogenase (ascorbate)
1.8.98: Other, known	CoB—CoM heterodisulfide reductase
1.8.99: Other	Sulfite reductase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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