Deoxyguanosine triphosphate

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Deoxyguanosine triphosphate
Names


IUPAC name 2′-Deoxyguanosine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name O¹-{[(2R,3S,5R)-5-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
CAS Number	2564-35-4^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:16497^N
ChEMBL	ChEMBL477486^N
ChemSpider	58613^Y
ECHA InfoCard	100.018.080
PubChem CID	65103
UNII	8C2O37Y44Q^Y
CompTox Dashboard (EPA)	DTXSID60948499 DTXSID50917119, DTXSID60948499
InChI InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1^Y Key: HAAZLUGHYHWQIW-KVQBGUIXSA-N^Y
SMILES O=P(O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n1cnc2c1NC(=N/C2=O)\N)C[C@@H]3O
Properties
Chemical formula	C₁₀H₁₆N₅O₁₃P₃
Molar mass	507.181023
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Deoxyguanosine triphosphate^[1] (dGTP) is a nucleoside triphosphate, and a nucleotide precursor used in cells for DNA synthesis. The substance is used in the polymerase chain reaction technique, in sequencing, and in cloning. It is also the competitor of inhibition onset by acyclovir in the treatment of HSV virus.^[2]

References

^ Nelson, David L.; Cox, Michael M. (2005). Principles of Biochemistry (4th ed.). New York: W. H. Freeman. ISBN 0-7167-4339-6.
^ Furman PA, Lambe CU, Nelson DJ (July 1982). "Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1". Am. J. Med. 73 (1A): 14–7. doi:10.1016/0002-9343(82)90056-0. PMID 6285704.

Nucleic acid constituents

Ribonucleoside	Adenosine Guanosine 5-Methyluridine Uridine 5-Methylcytidine Cytidine Pseudouridine Inosine N⁶-Methyladenosine Xanthosine Wybutosine
Deoxyribonucleoside	Deoxyadenosine Deoxyguanosine Thymidine Deoxyuridine Deoxycytidine Deoxyinosine Deoxyxanthosine

Nucleotide
(Nucleoside monophosphate)

Ribonucleotide	AMP GMP m⁵UMP UMP CMP IMP XMP
Deoxyribonucleotide	dAMP dGMP dTMP dUMP dCMP dIMP dXMP
Cyclic nucleotide	cAMP cGMP c-di-GMP c-di-AMP cADPR cGAMP

Nucleoside diphosphate

ADP GDP m⁵UDP UDP CDP Xanthosine diphosphate
dADP dGDP dTDP dUDP dCDP

ATP GTP m⁵UTP UTP CTP ITP XTP
dATP dGTP dTTP dUTP dCTP dITP dXTP

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