From Wikipedia, the free encyclopedia
dimethylglycine oxidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 1.5.3.10 | ||||||||
CAS no. | 74870-79-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, a dimethylglycine oxidase (EC 1.5.3.10) is an enzyme that catalyzes the chemical reaction
- N,N-dimethylglycine + H2O + O2 sarcosine + formaldehyde + H2O2
The 3 substrates of this enzyme are N,N-dimethylglycine, H2O, and O2, whereas its 3 products are sarcosine, formaldehyde, and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N,N-dimethylglycine:oxygen oxidoreductase (demethylating). It employs one cofactor, FAD.
Structural studies
[edit]As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1PJ5, 1PJ6, and 1PJ7.
References
[edit]- Mori N, Kawakami B, Tani Y, Yamada H (1980). "Purification and properties of dimethylglycine oxidase from Cylindrocarpon didymum M-1". Agric. Biol. Chem. 44 (6): 1383–1389. doi:10.1271/bbb1961.44.1383.
Oxidoreductases: CH-NH (EC 1.5) | |
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1.5.1: NAD or NADP acceptor | |
1.5.3: oxygen acceptor | |
1.5.5: quinone acceptor | |
1.5.99 |
Activity | |
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Regulation | |
Classification | |
Kinetics | |
Types |
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