Dorothy Warburton

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Dorothy Warburton

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Dorothy Warburton
Born	(1936-01-12)12 January 1936 Galt, Ontario, Canada
Died	(2016-04-26)26 April 2016 (aged 80) Englewood, New Jersey, United States
Alma mater	McGill University
Known for	Research contributions to the epidemiology of spontaneous abortion
Spouse	Frederick Warburton
Children	4
Awards	William Allan Award
Scientific career
Fields	Human genetics and cytogenetics^[1]
Institutions	Columbia University
Academic advisors	Clarke Fraser

Dorothy Pamela (DeMontmerency) Warburton (12 January 1936 – 26 April 2016)^[2] was a Canadian^[3] geneticist whose research focused on fetal chromosomal abnormalities and reasons for miscarriage.^[3]^[4]^[5]^[6] She died at the age of 80 on 26 April 2016 at her home in Englewood, New Jersey.^[4]

Early life and education

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Dorothy Pamela DeMontmerency was born in the town of Galt, Ontario on January 12, 1936.^[7] Her father worked as an industrial chemist while her mother stayed at home to take care of her and her siblings. She took a liking to biology and natural history from an early age and was especially interested in cytogenetics. This interest carried her through her education and she graduated from McGill University in 1957 with a degree in genetics. She continued her work in genetics at McGill under well-known medical geneticist Clarke Fraser. She completed her doctoral degree in 1961 where her work focused on the recurrence risk of spontaneous abortions.^[7]

Career

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In 1964, Dorothy moved to New York City and took a position as a faculty member at Barnard College of Columbia University.^[7] Here, she started training as a human cytogeneticist in the Department of Obstetrics and Gynecology at the Columbia University College of Physicians and Surgeons.^[7] Through her time working in the department she quickly recognized the need for a clinical genetic testing lab in the area. In 1969, she founded the Cytogenetics Laboratory at the NewYork-Presbyterian Hospital and Babie's Hospital that was affiliated with the College of Physicians and Surgeons.^[7] She was director of the lab for 37 years and remained an associate director until her death. Dorothy’s research over the years of her career centered on four overlapping themes:^[5]^[6]^[7]

Clinical and research cytogenetics.
The epidemiology of cytogenetic abnormalities.
The epidemiology of human spontaneous abortion.
The pathology of spontaneous abortion.

Personal life

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Dorothy married fellow McGill graduate student Frederick Toney Warburton in 1957. Together they had four children. Dorothy was a big advocate of women balancing both demanding careers and family at the same time. She was frequently met with criticism throughout her career and was denied faculty appointments and tenure because she was a woman in science.^[5]^[7]

Dorothy shared a rare immune disorder with three of her four children. This condition was known as a neutrophil chemotactic defect and her and her children often suffered from eczema, asthma, and severe allergies. Due to complications from the condition, one of her daughters unexpectedly died at the age of 24.^[8]

Achievements and awards

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Throughout her career, Dorothy was honoured with many awards and held many achievements and accomplishments. She received the William Allan Award in 2006 for her contributions to medicine and human genetics.^[3]^[4]^[9]^[10] Her lab was also one of the first lab's to use in situ hybridization for human gene mapping and were able to identify the sites of ribosomal RNA genes. For this she received the 2014 Distinguished Cytogeneticist Award from the American Cytogenetics Conference.^[1]

References

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^ ^a ^b Warburton, Peter E. (30 April 2014). "43rd Biennial American Cytogenetics Conference". American Cytogenetics Conference: 3–4. doi:10.1159/000360710. Retrieved 9 June 2016. {{cite journal}}: Cite journal requires |journal= (help)
^ Pioneering geneticist Dorothy Warburton of Englewood dies at 80 Archived 8 May 2016 at the Wayback Machine
^ ^a ^b ^c Jacobs, Patricia A. (October 2007). "Introductory Speech for Dorothy Warburton". The American Journal of Human Genetics. 81 (4). US National Library of Medicine: 646–7. doi:10.1086/521403. PMC 2227912. PMID 20529612.
^ ^a ^b ^c Levin, Jay (4 May 2016). "Pioneering geneticist Dorothy Warburton of Englewood dies at 80". The Record. Archived from the original on 8 May 2016. Retrieved 9 June 2016.
^ ^a ^b ^c May, Kate (29 April 2016). "7 lessons about finding the work you were meant to do". IDEAS.TED.COM. TED. Retrieved 9 June 2016. From scientist Dorothy Warburton who dealt with extreme sexism as she conducted research to break the stigma around miscarriage.
^ ^a ^b "Dorothy Warburton, Ph.D. Bio Sketch" (PDF). bioethics. Retrieved 9 June 2016.
^ ^a ^b ^c ^d ^e ^f ^g Terry Hassold; Ernest B. Hook; Patricia A. Jacobs (2016). "Dorothy Warburton(1936-2016)". The American Journal of Human Genetics. 99: 5–7. doi:10.1016/j.ajhg.2016.06.006.
^ Jerry C. Jacobs; Michael E. Morgan (1977). "A Familial Defect of Neutrophil Chemotaxis with Asthma, Eczema, and Recurrent Skin Infections". Pediatric Research. 11 (6): 732–736. doi:10.1203/00006450-197706000-00007. PMID 865918.
^ "ASHG Announces 2015 Award Recipients". ASHG. The American Society of Human Genetics. Archived from the original on 3 October 2014. Retrieved 9 June 2016.
^ Warburton, Dorothy (October 2007). "2006 William Allan Award Address: Having It All". The American Journal of Human Genetics. 81 (4): 648–656. doi:10.1086/521405. PMC 2227913. PMID 20529613.

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