Estradiol 17beta-dehydrogenase

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estradiol 17-beta-dehydrogenase

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In enzymology, an estradiol 17beta-dehydrogenase (EC 1.1.1.62) is an enzyme that catalyzes the chemical reaction

estradiol-17beta + NAD(P)+

\rightleftharpoons

estrone + NAD(P)H + H⁺

The 3 substrates of this enzyme are estradiol-17beta, NAD⁺, and NADP⁺, whereas its 4 products are estrone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is estradiol-17beta:NAD(P)⁺ 17-oxidoreductase. Other names in common use include 20alpha-hydroxysteroid dehydrogenase, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Structural studies

As of late 2007, 29 structures have been solved for this class of enzymes, with PDB accession codes 1A27, 1BHS, 1DHT, 1EQU, 1FDS, 1FDT, 1FDU, 1FDV, 1FDW, 1GZ6, 1I5R, 1IKT, 1IOL, 1JTV, 1QYV, 1QYW, 1QYX, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1YB1, 1ZQ5, 2F38, 2FGB, 2HQ1, 2PD6, and 3DHE.

References

Kautsky MP, Hagerman DD (1970). "17β-Estradiol Dehydrogenase of Ovine Ovaries". J. Biol. Chem. 245 (8): 1978–84. doi:10.1016/S0021-9258(18)63194-1. PMID 4314937.
Langer LJ, Alexander JA, Engel LL (1959). "Human Placental Estradiol-17β Dehydrogenase. II. Kinetics and substrate specificities". J. Biol. Chem. 234 (10): 2609–14. doi:10.1016/S0021-9258(18)69746-7. PMID 14413943.

v t e Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Phosphogluconate dehydrogenase Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3β 3β-HSD NSDHL 11β 11β-HSD1 11β-HSD2 17β
1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)
1.1.3: oxygen acceptor	Glucose oxidase L-gulonolactone oxidase Xanthine oxidase Alcohol oxidase
1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)
1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase
1.1.99: other acceptors	Choline dehydrogenase L2HGDH

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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