File:MecA Resistance.svg

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File:MecA Resistance.svg - Wikipedia

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DescriptionMecA Resistance.svg	English: Diagram depicting one recognized way in which bacteria may be resistant to antibiotics: if the antibiotic functions by blocking the active site of the enzyme, the bacteria may evolve to produce an enzyme that will not allow the antibiotic to bind to its active site. (This diagram is modeled specifically on the way some strains of Staphylococcus aureus have evolved to resist the beta-lactam antibiotic methicillin by expressing the mecA gene.) 1- Both enzymes are structurally similar, but differ in the kind of substances they will allow in their active sites. (The differences between the two may actually be much more subtle than what is implied by the image.) 2- Both enzymes carry out normal functions in the bacterial cell. (In this case, the enzymes are depicted making cross-links in the bacterial cell wall, a function which is crucial to bacterial cell survival and replication.) 3- The beta-lactam antibiotic fits in the active site of the antibiotic-sensitive enzyme, but not in that of the resistant enzyme. 4- Once in the active site, the beta-lactam ring of the antibiotic springs open, permanently inactivating the sensitive enzyme. The resistant enzyme, however, is totally unaffected; it is free to continue carrying out its normal function in the bacteria.
Date	30 March 2011
Source	Own work
Author	Mcstrother
Other versions	[edit] Cross-linking of bacteria cell wall with no antibiotics. Action of penicillin Resistance to penicillin via modified cross-linking enzyme. Action of vancomycin and resistance via alteration of peptide side-chains. Spanish version.

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	Date/Time	Dimensions	User	Comment
current	01:45, 10 September 2011	1,549 × 647 (947 KB)	Mcstrother	Updated to reflect correct mechanism of cell wall cross-linking.
	15:09, 3 May 2011	1,549 × 647 (865 KB)	Mcstrother	Changed font to Liberation Sans to resolve overlap issues.
	03:37, 10 April 2011	1,549 × 647 (864 KB)	Mcstrother	Change carbohydrate chain color
	01:54, 5 April 2011	1,549 × 647 (862 KB)	Mcstrother	Added more labels for clarity.
	21:25, 30 March 2011	1,549 × 647 (876 KB)	Mcstrother	{{Information \|Description ={{en\|1=Diagram depicting one recognized way in which bacteria may be resistant to antibiotics: if the antibiotic functions by blocking to the active site of the enzyme, the bacteria may evolve to produce an enzyme th

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Usage on en.wikibooks.org
- Structural Biochemistry/Antibiotics
- Structural Biochemistry/Volume 3
Usage on es.teknopedia.teknokrat.ac.id
- Staphylococcus aureus
Usage on sh.wikipedia.org
- Meticilin rezistentni stafilokokus aureus
Usage on sl.wikipedia.org
- Odpornost proti antibiotikom
Usage on sr.wikipedia.org
- Метицилин резистентни стафилококус ауреус
Usage on sv.wikipedia.org
- Antibiotikaresistens
- Användare:LinneaGustafsson/sandlåda

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Short title	mecA Beta-lactam Resistance
Width	1548.9846
Height	646.85809

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