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Heck's disease
Other names	Multifocal epithelial hyperplasia

Specialty	Oral and maxillofacial surgery

Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the oral cavity.^[1]^[2]^: 411 Can present with slightly pale, smooth or roughened surface morphology. It is caused by the human papilloma virus types 13 and 32.^[3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies. It shows 'cobblestone' appearance clinically. It was first identified in the Aboriginal population of North America.^[4]

Over time, they will spontaneously regress without treatment.^[5] Possible treatment may be excisional biopsy for lesions of functional or aesthetic concern.^{[citation needed]}

References

^ Tenore, G.; Palaia, G.; Del Vecchio, A.; Galanakis, A.; Romeo, U. (2013-10-24). "Focal epithelial hyperplasia (Heck's disease)". Annali di Stomatologia. 4 (Suppl 2): 43. ISSN 1824-0852. PMC 3860189. PMID 24353818.
^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ James, William D.; Berger, Timothy; Elston, Dirk (2015). Andrews' Diseases of the Skin E-Book: Clinical Dermatology. Elsevier Health Sciences. p. 408. ISBN 9780323319690.
^ Archard, Howell O; Heck, John W; Stanley, Harold R (1965). "Focal epithelial hyperplasia: An unusual oral mucosal lesion found in Indian children". Oral Surgery, Oral Medicine, Oral Pathology. 20 (2): 201–12. doi:10.1016/0030-4220(65)90192-1. PMID 14322615.
^ Eversole, Lewis R. (2011). Clinical Outline of Oral Pathology: Diagnosis and Treatment. PMPH-USA. p. 285. ISBN 9781607950158. Retrieved 18 January 2018.

Human papillomavirus

Related
diseases

Cancers	Cervical cancer cancers Anal Vaginal Vulvar Penile Head and neck cancer (HPV-positive oropharyngeal cancer)
Warts	genital plantar flat Laryngeal papillomatosis Epidermodysplasia verruciformis Focal epithelial hyperplasia Papilloma
Others	Acrochordon (skin tags)

Vaccine

HPV vaccines
- Cervarix
- Gardasil

Screening

Pap test:
- stain
Bethesda system
- Cytopathology
- Cytotechnology
Experimental techniques:
- Speculoscopy
- Cervicography

Colposcopy

Biopsy histology	Cervical intraepithelial neoplasia (CIN) Koilocyte Vaginal intraepithelial neoplasia (VAIN) Vulvar intraepithelial neoplasia (VIN)
Treatment	Cervical conization Loop electrical excision procedure (LEEP)

History

Skin infections, symptoms and signs related to viruses

DNA virus

Herpesviridae

Alpha.

HSV	Herpes simplex Herpetic whitlow Herpes gladiatorum Herpes simplex keratitis Herpetic sycosis Neonatal herpes simplex Genital herpes Cold sore Eczema herpeticum Herpetiform esophagitis Herpetic gingivostomatitis
B virus	B virus infection
VZV	Chickenpox Herpes zoster Herpes zoster oticus Ophthalmic zoster Disseminated herpes zoster Zoster-associated pain Modified varicella-like syndrome

Beta.

Gamma.

Kaposi's sarcoma-associated herpesvirus
- Kaposi's sarcoma

Poxviridae

Ortho.	Variola Smallpox Alastrim Monkeypox virus Monkeypox Cowpox Vaccinia virus Vaccinia Generalized vaccinia Eczema vaccinatum Progressive vaccinia Buffalopox
Para.	Farmyard pox: Milker's nodule Bovine papular stomatitis Pseudocowpox Orf Sealpox
Other	Yatapoxvirus: Tanapox Yaba monkey tumor virus Molluscum contagiosum virus

Papillomaviridae

HPV	Wart/plantar wart Heck's disease Genital wart giant Laryngeal papillomatosis Butcher's wart Bowenoid papulosis Epidermodysplasia verruciformis Verruca plana Pigmented wart Verrucae palmares et plantares
Bovine papillomavirus Equine sarcoid

Parvoviridae

Parvovirus B19

Polyomaviridae

Merkel cell polyomavirus
- Merkel cell carcinoma

RNA virus

Paramyxoviridae	MeV Measles
Matonaviridae	Rubella virus Rubella Congenital rubella syndrome ("German measles")
Togaviridae	Alphavirus infection Chikungunya fever
Picornaviridae	Coxsackie A virus Hand, foot, and mouth disease Herpangina Foot-and-mouth disease virus Boston exanthem disease

Ungrouped

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