From Wikipedia, the free encyclopedia
Analgesic drug under development
Pharmaceutical compound
Clinical data | |
---|---|
Routes of administration | By mouth, topical |
ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
Chemical and physical data | |
Formula | C22H14F3NO5 |
Molar mass | 429.351 g·mol−1 |
3D model (JSmol) | |
| |
|
Funapide (INN) (former developmental code names TV-45070 and XEN402) is a novel analgesic under development by Xenon Pharmaceuticals (formerly in partnership with Teva Pharmaceutical Industries) for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain.[1][2][3][4] It acts as a small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker.[1][2][4] Funapide is being evaluated in humans in both oral and topical formulations, and as of July 2014, has reached phase IIb clinical trials.[1][3]
See also
[edit]References
[edit]- ^ a b c Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (August 2014). "Recent progress in sodium channel modulators for pain". Bioorganic & Medicinal Chemistry Letters. 24 (16): 3690–3699. doi:10.1016/j.bmcl.2014.06.038. PMID 25060923.
- ^ a b Ali Z, Palmer JE, Goli V (2013). "Anticonvulsants: Clinical". In McMahon S, Koltzenburg M, Tracey I, Turk DC (eds.). Wall & Melzack's Textbook of Pain (6 ed.). Elsevier Health Sciences. p. 508. ISBN 978-0-7020-4059-7. OCLC 1008841684.
- ^ a b "TV-45070: A Small Molecule for the Treatment of the Orphan Disease EM and Other Pain Disorders". Xenon Pharma. Archived from the original on 15 July 2013.
- ^ a b "Teva and Xenon Announce Teva's World Wide License of Xenon's Pain Drug XEN402". Xenon Pharma. 11 December 2012. Archived from the original on 26 July 2014. Retrieved 2014-07-20.
External links
[edit]- "Funapide - Flexion Therapeutics". AdisInsight. Springer Nature Switzerland AG.
Esters by acid |
| ||||||
---|---|---|---|---|---|---|---|
Amides | |||||||
Combinations | |||||||
|
Calcium |
| ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium |
| ||||||||||||||||||||||||
Sodium |
| ||||||||||||||||||||||||
Chloride |
| ||||||||||||||||||||||||
Others |
| ||||||||||||||||||||||||
Retrieved from "https://teknopedia.ac.id/w/index.php?title=Funapide&oldid=1224096418"
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url