GUF1

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GUF1

Identifiers

GUF1, EF-4, GUF1 homolog, GTPase, EIEE40, EF4, GTP binding elongation factor DEE40

External IDs

OMIM: 617064; MGI: 2140726; HomoloGene: 6505; GeneCards: GUF1; OMA:GUF1 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p12	Start	44,678,420 bp^[1]
Band	4p12	End	44,700,928 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 C3.1	Start	69,714,266 bp^[2]
Band	5\|5 C3.1	End	69,733,316 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

gastrocnemius muscle

biceps brachii

muscle of thigh

ganglionic eminence

Skeletal muscle tissue of rectus abdominis

Achilles tendon

anterior cingulate cortex

rectum

Skeletal muscle tissue of biceps brachii

Top expressed in

tail of embryo

ventricular zone

hand

neural layer of retina

otolith organ

right kidney

muscle of thigh

utricle

lens

superior frontal gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding GTP binding hydrolase activity GTPase activity ribosome binding
Cellular component	mitochondrial inner membrane membrane mitochondrion mitochondrial matrix
Biological process	protein biosynthesis positive regulation of translation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


60558


231279

Ensembl


ENSG00000151806


ENSMUSG00000029208

UniProt


Q8N442


Q8C3X4

RefSeq (mRNA)


NM_021927 NM_001345867 NM_001345868 NM_001345869


NM_172711 NM_182768 NM_001310631

RefSeq (protein)


NP_001332796 NP_001332797 NP_001332798 NP_068746


NP_001297560 NP_766299

Location (UCSC)

Chr 4: 44.68 – 44.7 Mb

Chr 5: 69.71 – 69.73 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

GUF1 homolog, GTPase is a protein that in humans is encoded by the GUF1 gene. ^[5] It is the mitochondrial homolog of elongation factor 4.

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151806 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029208 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GUF1 homolog, GTPase". Retrieved 2016-09-01.

Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.

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