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teknopedia

Flag Counter
  2. World Encyclopedia
  3. Gabamide - Wikipedia
Gabamide - Wikipedia
From Wikipedia, the free encyclopedia

Gabamide
Clinical data
Other namesGABAmide; GABAMIDE; GABA amide; 4-Aminobutanamide; 4-ABAD; 4-Aminobutyramide; gamma-Aminobutyramide; γ-Aminobutyramide; GABAD; gamma-Aminobutyric acid amide; γ-Aminobutyric acid amide
Drug classGABA receptor agonist
ATC code
  • None
Identifiers
  • 4-aminobutanamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.019.852 Edit this at Wikidata
Chemical and physical data
FormulaC4H10N2O
Molar mass102.137 g·mol−1
3D model (JSmol)
  • C(CC(=O)N)CN
  • InChI=1S/C4H10N2O/c5-3-1-2-4(6)7/h1-3,5H2,(H2,6,7)
  • Key:WCVPFJVXEXJFLB-UHFFFAOYSA-N

Gabamide, or GABAmide, also known as γ-aminobutyramide (GABAD), is a GABA receptor agonist and GABA analogue, or more specifically the amide of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).[1][2] Along with GABA and progabide acid (SL-75.102), gabamide is an active metabolite of the anticonvulsant drug progabide (Gabrene; SL-76.002).[1][2] Unlike progabide, but similarly to GABA, gabamide is unable to cross the blood–brain barrier and hence is peripherally selective.[2] However, gabamide and GABA are formed in the brain from progabide following its entry into this part of the body.[2]

See also

References

  1. ^ a b Bartholini G (1981). "Present Knowledge of GABA Receptor Agonists". Medicinal Chemistry Advances. Elsevier. pp. 345–353. doi:10.1016/b978-0-08-025297-1.50032-5. ISBN 978-0-08-025297-1. Retrieved 6 October 2025.
  2. ^ a b c d Bergmann KJ (1985). "Progabide: a new GABA-mimetic agent in clinical use". Clinical Neuropharmacology. 8 (1): 13–26. doi:10.1097/00002826-198503000-00002. PMID 2983890. Progabide, a new synthetic compound defined as the Schiff base of gamma-aminobutyramide and a substituted benzophenone, has been developed. Well absorbed, and relatively free of toxicity, it is both a direct GABA receptor agonist as well as an exogenous source of GABA. [...]
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