Gibberellin 3beta-dioxygenase

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gibberellin 3-beta-dioxygenase

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In enzymology, a gibberellin 3beta-dioxygenase (EC 1.14.11.15) is an enzyme that catalyzes the chemical reaction

gibberellin 20 + 2-oxoglutarate + O₂

\rightleftharpoons

gibberellin 1 + succinate + CO₂

The 3 substrates of this enzyme are gibberellin 20, 2-oxoglutarate, and O₂, whereas its 3 products are gibberellin 1, succinate, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as the oxidant. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and one atom of oxygen is incorporated into each donor. The systematic name of this enzyme class is (gibberellin-20), 2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating). Other names in common use include gibberellin 3beta-hydroxylase, (gibberrellin-20), 2-oxoglutarate: oxygen oxidoreductase and (3beta-hydroxylating). This enzyme participates in diterpenoid biosynthesis. It has 2 cofactors: iron and Ascorbate.

References

Kwak SS, Kamiya Y, Sakurai A, Takahishi N, Graebe JE (1988). "Partial-purification and characterization of gibberellin 3beta-hydroxylase from immature seeds of Phaseolus vulgaris L". Plant Cell Physiol. 29: 935–943.

v t e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate	Prolyl hydroxylase HIF prolyl-hydroxylase EGLN1 EGLN2 EGLN3 P4HTM Lysyl hydroxylase AlkB ALKBH1 FTO
1.14.13: NADH or NADPH	Flavin-containing monooxygenase FMO1 FMO2 FMO3 FMO4 FMO5 Nitric oxide synthase NOS1 NOS2 NOS3 Cholesterol 7 alpha-hydroxylase Methane monooxygenase 3A4 14α-demethylase 24-hydroxycholesterol 7α-hydroxylase
1.14.14: reduced flavin or flavoprotein	19A1 2D6 2E1
1.14.15: reduced iron–sulfur protein	11B1 11B2 11A1
1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase Tyrosine hydroxylase Tryptophan hydroxylase
1.14.17: reduced ascorbate	Dopamine beta-hydroxylase
1.14.18-19: other	Tyrosinase Stearoyl-CoA desaturase-1
1.14.99 - miscellaneous	Cyclooxygenase Heme oxygenase (HMOX1) Squalene monooxygenase 17A1 21A2 Ecdysone 20-monooxygenase Deoxyhypusine monooxygenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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