Glycine dehydrogenase (cyanide-forming)

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glycine dehydrogenase (cyanide-forming)

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In enzymology, a glycine dehydrogenase (cyanide-forming) (EC 1.4.99.5) is an enzyme that catalyzes the chemical reaction

glycine + 2 A

\rightleftharpoons

hydrogen cyanide + CO₂ + 2 AH₂

Thus, the two substrates of this enzyme are glycine and A, whereas its 3 products are hydrogen cyanide, CO₂, and AH₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. The systematic name of this enzyme class is glycine:acceptor oxidoreductase (hydrogen-cyanide-forming). Other names in common use include hydrogen cyanide synthase, and HCN synthase.

References

Wissing F (1975). "Cyanide production from glycine by a homogenate from a Pseudomonas species". J. Bacteriol. 121 (2): 695–9. PMC 245984. PMID 234422.
Castric PA (1977). "Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis". J. Bacteriol. 130 (2): 826–31. PMC 235287. PMID 233722.
Haas D; Blumer, C; Von Schroetter, C; Gaia, V; Défago, G; Keel, C; Haas, D (1998). "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0". J. Bacteriol. 180 (12): 3187–96. PMC 107821. PMID 9620970.
Blumer C, Haas D (2000). "Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis". Arch. Microbiol. 173 (3): 170–7. doi:10.1007/s002039900127. PMID 10763748.

v t e CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)
1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))
1.4.4: disulfide acceptor	Glycine cleavage system
1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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