From Wikipedia, the free encyclopedia
Gypenosides are triterpenoid saponins and are the main active components of Gynostemma pentaphyllum, a climbing plant in the family Cucurbitaceae.[1] They have been traditionally used in herbal medicine and have been shown to be effective in the treatment of cardiovascular diseases, although their mechanism of action is unknown.[2]
Gypenoside A has the chemical formula C46H74O17.[3]
References
[edit]- ^ Lu, Kung-Wen; Chen, Jung-Chou; Lai, Tung-Yuan; Yang, Jai-Sing; Weng, Shu-Wen; Ma, Yi-Shih; Tang, Nou-Ying; Lu, Pei-Jung; Weng, Jing-Ru; Chung, Jing-Gung (2010-05-01). "Gypenosides Causes DNA Damage and Inhibits Expression of DNA Repair Genes of Human Oral Cancer SAS Cells". In Vivo. 24 (3): 287–291. ISSN 0258-851X. PMID 20555000. Retrieved 2018-07-14.
- ^ Tanner, MA; Bu, X; Steimle, JA; Myers, PR (1999). "The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum". Nitric Oxide. 3 (5): 359–365. doi:10.1006/niox.1999.0245. PMID 10534439.
- ^ Pubchem. "Gypenoside A". Retrieved 2018-07-14.
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url
url