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HBXIP - Wikipedia

From Wikipedia, the free encyclopedia

LAMTOR5

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3MS6, 3MSH

Identifiers

Aliases

LAMTOR5, HBXIP, XIP, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

External IDs

OMIM: 608521; MGI: 1915826; HomoloGene: 4668; GeneCards: LAMTOR5; OMA:LAMTOR5 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p13.3	Start	110,401,249 bp^[1]
Band	1p13.3	End	110,407,942 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F2.3	Start	107,186,174 bp^[2]
Band	3\|3 F2.3	End	107,191,398 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

kidney tubule

islet of Langerhans

palpebral conjunctiva

monocyte

human kidney

apex of heart

muscle of thigh

left ventricle

anterior pituitary

glomerulus

Top expressed in

right kidney

yolk sac

facial motor nucleus

medial ganglionic eminence

proximal tubule

human kidney

endocardial cushion

embryo

anterior horn of spinal cord

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity protein binding molecular adaptor activity
Cellular component	cytoplasm cytosol Ragulator complex lysosomal membrane lysosome
Biological process	regulation of cell size negative regulation of cysteine-type endopeptidase activity involved in apoptotic process viral genome replication response to virus negative regulation of apoptotic process protein localization to lysosome cellular response to amino acid stimulus positive regulation of TOR signaling regulation of macroautophagy positive regulation of TORC1 signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10542


68576

Ensembl


ENSG00000134248


ENSMUSG00000087260

UniProt


O43504


Q9D1L9

RefSeq (mRNA)


NM_006402 NM_001382293


NM_026774

RefSeq (protein)


NP_006393 NP_001369222 NP_006393.2


NP_081050

Location (UCSC)

Chr 1: 110.4 – 110.41 Mb

Chr 3: 107.19 – 107.19 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.^[5]^[6]

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.^[6]

Interactions

HBXIP has been shown to interact with NCOA6.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134248 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000087260 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Melegari M, Scaglioni PP, Wands JR (March 1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication". Journal of Virology. 72 (3): 1737–43. doi:10.1128/jvi.72.3.1737-1743.1998. PMC 109461. PMID 9499022.
^ ^a ^b "Entrez Gene: HBXIP hepatitis B virus x interacting protein".
^ Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.

Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (March 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". The Journal of Biological Chemistry. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
Li Y, Lu YY (April 2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World Journal of Gastroenterology. 8 (2): 213–6. doi:10.3748/wjg.v8.i2.213. PMC 4658353. PMID 11925594.
Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, Reed JC (June 2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression". The EMBO Journal. 22 (11): 2729–40. doi:10.1093/emboj/cdg263. PMC 156760. PMID 12773388.
Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.
Lee SH, Park SG, Lim SO, Jung G (June 2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1741 (1–2): 75–84. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.
Lee AT, Ren J, Wong ET, Ban KH, Lee LA, Lee CG (September 2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage". The Journal of Biological Chemistry. 280 (39): 33525–35. doi:10.1074/jbc.M506628200. PMID 16055925.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Minczuk M, Mroczek S, Pawlak SD, Stepien PP (October 2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". The FEBS Journal. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273. S2CID 40846992.
Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, Shao RX, Dharel N, Tanaka Y, Ohta M, Tateishi R, Shiina S, Tatsukawa M, Fukai K, Imazeki F, Yokosuka O, Shiratori Y, Omata M (December 2006). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma". Journal of Hepatology. 45 (6): 805–12. doi:10.1016/j.jhep.2006.07.025. PMID 17050029.
Chen J, Siddiqui A (June 2007). "Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress". Journal of Virology. 81 (12): 6757–60. doi:10.1128/JVI.00172-07. PMC 1900104. PMID 17428866.

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