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HIST2H3C - Wikipedia

From Wikipedia, the free encyclopedia

H3C14

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2IIJ, 2X4W, 2X4X, 2X4Y, 3AV1, 3DB3, 3MO8, 3R93, 4MZF, 4MZG, 4MZH, 4OUC, 5BO0, 2HIO, 5B0Z, 2ARO, 1EQZ, 1HQ3, 4KGC, 1TZY, 4UUZ, 2F8N, 5B0Y, 4LD9, 5B40, 5CIU

Identifiers

Aliases

H3C14, H3, H3.2, H3/M, H3F2, H3FM, H3FN, histone cluster 2, H3c, histone cluster 2 H3 family member c, HIST2H3C, H3 clustered histone 14, H3C15, H3C13

External IDs

OMIM: 142780; MGI: 3650546; HomoloGene: 134475; GeneCards: H3C14; OMA:H3C14 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.2	Start	149,840,687 bp^[1]
Band	1q21.2	End	149,841,208 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bone marrow cells

epithelium of colon

ganglionic eminence

ventricular zone

right uterine tube

Cerebellum

cerebellar cortex

cerebellar hemisphere

right hemisphere of cerebellum

gonad

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein heterodimerization activity DNA binding histone binding protein binding chromatin binding nucleosomal DNA binding
Cellular component	extracellular exosome extracellular region nucleoplasm chromosome nucleosome nucleus chromatin
Biological process	epigenetic maintenance of chromatin in transcription-competent conformation blood coagulation rDNA heterochromatin assembly nucleosome assembly negative regulation of gene expression, epigenetic negative regulation of transcription by RNA polymerase II chromatin organization regulation of gene silencing by miRNA interleukin-7-mediated signaling pathway regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


126961


625328

Ensembl


ENSG00000203811


ENSMUSG00000082029

UniProt


Q71DI3


P02301

RefSeq (mRNA)


NM_021059


NM_001370931

RefSeq (protein)


NP_066403 NP_001116847


XP_894986

Location (UCSC)

Chr 1: 149.84 – 149.84 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene.^[4]^[5]^[6]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.^[6]

Interactions

HIST2H3C has been shown to interact with NCOA6.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000203811 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ Marashi F, Helms S, Shiels A, Silverstein S, Greenspan DS, Stein G, Stein J (Jul 1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences". Biochem Cell Biol. 64 (4): 277–289. doi:10.1139/o86-039. PMID 3013246.
^ ^a ^b "Entrez Gene: HIST2H3C histone cluster 2, H3c".
^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. 23 (1): 140–149. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968.

External links

Overview of all the structural information available in the PDB for UniProt: Q71DI3 (Histone H3.2) at the PDBe-KB.

PDB gallery

1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
1f66: 2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z
1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE
1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution
1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution
1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution
1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1s32: Molecular Recognition of the Nucleosomal 'Supergroove'
1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution
1u35: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
1zbb: Structure of the 4_601_167 Tetranucleosome
1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core
2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione
2cv5: Crystal structure of human nucleosome core particle
2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes
2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element
2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN
2hue: Structure of the H3-H4 chaperone Asf1 bound to histones H3 and H4
2io5: Crystal structure of the CIA- histone H3-H4 complex
2nzd: Nucleosome core particle containing 145 bp of DNA

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