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Hippocalcin - Wikipedia

From Wikipedia, the free encyclopedia

HPCA

Identifiers

Aliases

HPCA, BDR2, DYT2, hippocalcin

External IDs

OMIM: 142622; MGI: 1336200; HomoloGene: 55634; GeneCards: HPCA; OMA:HPCA - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p35.1	Start	32,885,994 bp^[1]
Band	1p35.1	End	32,898,441 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D2.2	Start	129,005,363 bp^[2]
Band	4\|4 D2.2	End	129,015,829 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

caudate nucleus

middle frontal gyrus

putamen

nucleus accumbens

external globus pallidus

prefrontal cortex

right frontal lobe

Region I of hippocampus proper

Brodmann area 10

dorsolateral prefrontal cortex

Top expressed in

CA3 field

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

olfactory tubercle

primary visual cortex

hippocampus proper

Region I of hippocampus proper

nucleus accumbens

perirhinal cortex

globus pallidus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	metal ion binding actin binding calcium ion binding identical protein binding kinase binding
Cellular component	perikaryon dendrite membrane neuronal cell body membrane axon dendritic spine head dendrite cytoplasm cytosol extrinsic component of membrane cytoplasm membrane postsynapse glutamatergic synapse
Biological process	positive regulation of adenylate cyclase activity response to organic cyclic compound cellular response to monosodium glutamate negative regulation of guanylate cyclase activity positive regulation of phospholipase activity activation of phospholipase D activity brain development retina development in camera-type eye response to ketamine response to L-glutamate inner ear development response to Aroclor 1254 calcium-mediated signaling positive regulation of protein targeting to membrane cellular response to electrical stimulus cellular response to calcium ion regulation of voltage-gated calcium channel activity regulation of postsynaptic neurotransmitter receptor internalization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3208


15444

Ensembl


ENSG00000121905


ENSMUSG00000028785

UniProt


P84074


P84075

RefSeq (mRNA)


NM_002143


NM_001130419 NM_010471 NM_001286081 NM_001286083

RefSeq (protein)


NP_002134


NP_001123891 NP_001273010 NP_001273012 NP_034601

Location (UCSC)

Chr 1: 32.89 – 32.9 Mb

Chr 4: 129.01 – 129.02 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Hippocalcin is a protein that in humans is encoded by the HPCA gene.^[5]^[6]

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.^[7]^[8] It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.^[9]

Processes

Hippocalcin takes part in the following processes:

Activation of PLD1 and PLD2 expression
Inhibition of apoptosis
MAP kinase signalling
Involved in long term depression in hippocampal neuron
Required for normal spatial learning

Interactions

Hippocalcin interacts with following proteins:

Neuronal apoptosis inhibitory protein (NAIP)
Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
The b2 adaptin of the AP2 complex
Calcium-dependent activator protein for secretion (CADPS)

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121905 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028785 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. doi:10.1006/bbrc.1994.1491. PMID 8166736.
^ Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene. 225 (1–2): 117–24. doi:10.1016/S0378-1119(98)00526-5. PMID 9931466.
^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.
^ O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. doi:10.1083/jcb.200306042. PMC 2173692. PMID 14638856.

External links

NCS proteins

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Adhesion molecules	Cadherins CDH1 CDH2 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CDH10 CDH11 CDH12 CDH13 CDH14 CDH15 CDH16 CDH17
Calcium channels	Ligand-gated 5-HT3 receptor Ionotropic glutamate receptors AMPA receptors Kainate receptors NMDA receptors P2X receptors Voltage-gated L N P R T TRP channels TRPA TRPC TRPV
Calcium pumps	Sodium-calcium exchangers SLC3A2 SLC8A1
GPCRs	Calcium-sensing receptor
Annexins	A1 A2 A3 A4 A5 A6 A7 A8 A8-L2 A9 A10 A11 A12 A13

Intracellular signaling

Second messengers	IP3 NAADP cADPR
Intracellular channels	IP3 receptor Ryanodine receptor Calcium-induced calcium release
Intracellular pumps	SERCA ATP2A1 ATP2A2 ATP2A3 Sodium-calcium exchangers SLC8B1 SLC24A5
Sensors and chelators	Calbindin Calmodulin CALM1 CALM2 CALM3 CALML3 CALML5 Calsequestrin Calretinin Gelsolin Neuronal calcium sensors Calsenilin Frequenin GUCA 1A 1B Hippocalcin Neurocalcin Recoverin Visinin Parvalbumin Phospholamban Sarcalumenin Synaptotagmins SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT9 SYT11 SYT13 SYT14 S100 S100P Troponin C TNNC1 TNNC2
Calcium-dependent chaperones	Calreticulin Calnexin HSPA5 HSP90B1
Calcium-dependent kinases	CaM kinases CAMK1 CAMK2 A B D G CAMK3 CAMK4 Protein kinase C
Calcium-dependent proteases	Calpains CAPN1 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10
Indirect regulators	Calcitonin Parathyroid hormone Vitamin D Vitamin K

Extracellular chelators

Extracellular matrix proteins	Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix gla protein Osteonectin SIBLINGs Bone sialoprotein Dentin matrix phosphoprotein Dentin sialophosphoprotein Osteopontin
Secreted hormones	Osteocalcin

Calcium-binding domains

Categories:

Hidden categories:

Processes

Interactions

References

Further reading

External links