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ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication.^[1] It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of double-stranded DNA (dsDNA);^[1] its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg²⁺-independent.^[1] In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme.^[2]

References

^ ^a ^b ^c Boehmer, PE; Lehman, IR (1993). "Herpes simplex virus type 1 ICP8: Helix-destabilizing properties". Journal of Virology. 67 (2): 711–5. PMC 237422. PMID 8380461.
^ Zhou, C; Knipe, DM (2002). "Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme". Journal of Virology. 76 (12): 5893–904. doi:10.1128/JVI.76.12.5893-5904.2002. PMC 136207. PMID 12021322.

External links

ICP8 on UniProt

Viral proteins (early and late)

DNA

linear ds-DNA
(Duplodnaviria,
Varidnaviria)

Herpes simplex

VSPs:

capsid:	HHV capsid portal protein Herpesvirus glycoprotein B

VNPs:

Vaccinia

VNPs:	B13R

Adenoviridae

VNPs:	E1A E1B

circular ds-DNA
(Duplodnaviria,
Varidnaviria?)

Epstein–Barr

VSPs:	LMP-1 LMP-2
VNPs:	EBNA-1 EBNA-2 EBNA-3
ncRNA:	EBER

Baculoviridae

VNPs:	Early 35 kDa protein

other
(Riboviria,
Monodnaviria)

Polyomaviridae
(SV40, MPyV, MCPyV, HaPyV)
(non-enveloped circular ds-DNA)

VSPs:

capsid:	VP1 VP2 and VP3

VNPs:

oncoprotein:	STag MTag LTag (SV40 Tag)

Agnoprotein

Hepatitis B
(circular partially ds-DNA)

VSPs:	HBsAg HBcAg HBeAg
VNPs:	HBx Hepatitis B virus DNA polymerase

RNA

ds-RNA
(Riboviria)

Rotavirus
(Duplornaviricota)

VNPs:	NSP1 NSP2 NSP3 NSP4 NSP5 NSP6

Rhinov., Polio, Hep A,
etc. (Pisuviricota)

VNPs:	VPg

ss-RNA
positive-sense
(Riboviria)

Hepatitis C
(Kitrinoviricota)

VSPs:	viral envelope E1 E2
VNPs:	P7 NS2 NS3 NS4A NS4B NS5A NS5B

SARS-CoV-2
(Pisuviricota)

VSPs:	viral envelope Spike Envelope Membrane Nucleocapsid
VNPs:	ORF1ab 3C-like protease (NS5) ORF3a ORF3b ORF3c ORF3d ORF6 ORF7a ORF7b ORF8 ORF9b

ss-RNA
negative-sense
(Negarnaviricota)

Influenza virus

VSPs:

capsid:	matrix protein M1 protein viral envelope M2 protein
glycoprotein:	Influenza hemagglutinin Neuraminidase HA-tag

VNPs:

Parainfluenza

VSPs:

glycoprotein:	Parainfluenza hemagglutinin-neuraminidase

Mumps

VSPs:

glycoprotein:	Mumps hemagglutinin-neuraminidase

Measles

VSPs:

glycoprotein:	Measles hemagglutinin

RSV

VSPs:

glycoprotein:	Respiratory syncytial virus G protein

Zaire ebolavirus

VSPs:

capsid:	matrix protein VP40 VP24

Indiana vesiculovirus

VSPs:

capsid:	matrix protein Vesiculovirus matrix proteins

Structure and genome of HIV

VSPs:	gag p24 pol Integrase Reverse transcriptase HIV-1 protease env gp120 gp41
VRAPs:	transactivators Tat Rev Vpr Nef Vif Vpu or Vpx

Multiple

- Rous sarcoma virus
- murine leukemia virus

Fusion protein

oncoprotein:	Gag-onc fusion protein

Categories:

See also

References

External links