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IFT57 - Wikipedia

From Wikipedia, the free encyclopedia

IFT57

Identifiers

Aliases

IFT57, ESRRBL1, HIPPI, MHS4R2, intraflagellar transport 57, OFD18

External IDs

OMIM: 606621; MGI: 1921166; HomoloGene: 32383; GeneCards: IFT57; OMA:IFT57 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q13.12-q13.13	Start	108,160,812 bp^[1]
Band	3q13.12-q13.13	End	108,222,435 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 B5	Start	49,519,596 bp^[2]
Band	16\|16 B5	End	49,585,489 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

sperm

caput epididymis

left testis

mucosa of paranasal sinus

right testis

olfactory zone of nasal mucosa

epithelium of nasopharynx

corpus epididymis

right uterine tube

Top expressed in

Epithelium of choroid plexus

fossa

islet of Langerhans

seminiferous tubule

condyle

ciliary body

barrel cortex

vestibular sensory epithelium

lateral geniculate nucleus

medial geniculate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding protein binding
Cellular component	intraciliary transport particle B cytoplasm ciliary basal body centrosome Golgi apparatus cell projection photoreceptor connecting cilium dendrite terminus ciliary tip axoneme cytoskeleton cilium
Biological process	regulation of apoptotic process regulation of transcription, DNA-templated intraciliary transport transcription, DNA-templated heart looping neural tube closure negative regulation of epithelial cell proliferation smoothened signaling pathway left/right pattern formation activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process intraciliary transport involved in cilium assembly motile cilium assembly non-motile cilium assembly cilium assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55081


73916

Ensembl


ENSG00000114446


ENSMUSG00000032965

UniProt


Q9NWB7


Q8BXG3

RefSeq (mRNA)


NM_018010


NM_028680

RefSeq (protein)


NP_060480


NP_082956

Location (UCSC)

Chr 3: 108.16 – 108.22 Mb

Chr 16: 49.52 – 49.59 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.^[5]

Interactions

IFT57 has been shown to interact with Caspase 8.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114446 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032965 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IFT57 intraflagellar transport 57 homolog (Chlamydomonas)".
^ Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (Feb 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820. S2CID 10439592.

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820. S2CID 10439592.
Mattson MP (2002). "Accomplices to neuronal death". Nature. 415 (6870): 377–9. doi:10.1038/415377a. PMID 11807533. S2CID 39428123.
Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY (2003). "The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1". Biochem. Biophys. Res. Commun. 305 (2): 359–64. doi:10.1016/S0006-291X(03)00764-2. PMID 12745083.
Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC (2003). "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia". J. Biol. Chem. 278 (36): 34211–8. doi:10.1074/jbc.M300156200. PMID 12821668.
Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR (2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome". Nat. Genet. 36 (9): 989–93. doi:10.1038/ng1414. PMID 15314642.
Majumder P, Chattopadhyay B, Mazumder A, Das P, Bhattacharyya NP (2006). "Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1". Neurobiol. Dis. 22 (2): 242–56. doi:10.1016/j.nbd.2005.11.003. PMID 16364650. S2CID 23232258.
Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U (2006). "Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1". Acta Crystallographica Section F. 62 (Pt 12): 1247–50. doi:10.1107/S1744309106046628. PMC 2225382. PMID 17142908.
Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D, Bhattacharyya NP (2007). "Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo". Biochem. Biophys. Res. Commun. 353 (1): 80–5. doi:10.1016/j.bbrc.2006.11.138. PMID 17173859.

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