Iowa Highway 64
Iowa 64 highlighted in red
Route information
Maintained by Iowa DOT
Length	64.355 mi[1] (103.569 km)
Tourist routes	Grant Wood Scenic Byway
Major junctions
West end	US 151 in Anamosa
Major intersections	US 61 in Maquoketa US 67 / Great River Road near Sabula US 52 / Great River Road near Sabula
East end	US 52 / IL 64 at Savanna
Location
Country	United States
State	Iowa
Counties	Jones Jackson
Highway system
Iowa Primary Highway System Interstate US State Secondary Scenic
← US 63 → US 65

Iowa Highway 64 (Iowa 64) is a 64-mile-long (103 km) state highway that runs through two counties in east central Iowa. It begins at an interchange with U.S. Route 151 (US 151) in Anamosa and ends at the Dale Gardner Veterans Memorial Bridge over the Mississippi River near Sabula. It continues through Illinois as Illinois Route 64. The western half of the highway is the Grant Wood Scenic Byway. Originally, Iowa 64 spanned the length of the state and began at the Missouri River in Council Bluffs where it connected to N-64 in Omaha. It headed northeast and east on highways that today are roughly parallel to Interstate 80 (I-80) and US 30. In 1969, however, Iowa 64 was shortened to its current routing.

Iowa 64 begins at an interchange with US 151 in Anamosa. West of the interchange, the road is County Road E28 (CR E28), which becomes Third Street in Anamosa, while to the east, Iowa 64 begins its eastward trek. It leaves Anamosa heading to the south-southeast. After an S curve that takes the road to the south and then back east, the highway passes Antioch School, which Iowa painter Grant Wood attended for four years.^[2]

Iowa 38 overlaps Iowa 64 for the next two miles (3.2 km) before splitting off to the north. Iowa 64 continues east for another 5 miles (8.0 km) and arrives in the town of Wyoming. Upon arriving in Wyoming, Iowa 64 meets with another north–south state highway, this time Iowa 136. At the eastern end of Wyoming, Iowa 64 / Iowa 136 come to a T intersection where the original stretch of Iowa 64 comes to an end. Iowa 136 splits off to the south, while Iowa 64 splits off to the north very briefly before curving eastbound once again. Five miles (8.0 km) after leaving Wyoming, Iowa 64 enters Jackson County. Iowa 64 passes through the small towns of Monmouth and Baldwin and bypasses the village of Nashville before arriving in Maquoketa, the seat of Jackson County.

Iowa 64 intersects US 61 in western Maquoketa. The stretch of Iowa 64 between US 61 and Main Street in Maquoketa is a part of US 61 Business. At the eastern city limits of Maquoketa, Iowa 64 intersects with Iowa 62 which heads north-northeast from Maquoketa towards Bellevue. After Maquoketa, Iowa 64 continues east through rolling farmland before descending into the Goose Lake Channel^[3][4] and intersects CR Z20, formerly Iowa 113, near Spragueville. Iowa 64 leaves the Goose Lake Channel east of Preston.

About seven miles (11 km) east of Miles, Iowa 64 meets US 67, which joins Iowa 64 from the south for its last one-half mile (800 m). US 67 ends at the intersection with US 52 west of Sabula. Iowa 64 and US 52 overlap each other for their last four miles (6.4 km) in Iowa. Before entering Sabula, US 52 / Iowa 64 cross the Mississippi River backwater Sabula Lakes causeway. North of Sabula, the US 52 / Iowa 64 causeway divides the Mississippi River from Sheepshead Bay, another backwater area. At this point, US 52 / Iowa 64, directionally signed south and east, respectively, are heading north. US 52 / Iowa 64 turn east and cross the main channel of the Mississippi River on the Dale Gardner Veterans Memorial Bridge, becoming US 52 / Illinois Route 64 (IL 64). Immediately after entering Illinois at Savanna, US 52/ IL 64 intersect IL 84. Illinois Route 64 provides a direct link to Chicago.

County	Location	mi[1]	km	Destinations	Notes
Jones	Anamosa	0.000	0.000	US 151 / CR E28 west / Grant Wood Scenic Byway – Cedar Rapids, Dubuque
	Jackson Township	7.861	12.651	Iowa 38 south – Olin	Western end of Iowa 38 overlap
	Madison Township	9.868	15.881	Iowa 38 north – Monticello	Eastern end of Iowa 38 overlap
	Wyoming	14.319	23.044	Iowa 136 north – Onslow, Cascade	Western end of Iowa 136 overlap
		15.281	24.592	Iowa 136 south – Oxford Junction	Eastern end of Iowa 136 overlap
Jackson	Maquoketa	32.869	52.898	US 61 – Dubuque, Davenport
		34.713	55.865	Iowa 62 north / Grant Wood Scenic Byway – Andrew, Bellevue
	Union Township	60.134	96.776	US 67 south / Great River Road south – Clinton	Western end of US 67 overlap
		60.601	97.528	US 52 north / US 67 ends / Great River Road north – Bellevue	National end of US 67; western end of US 52 overlap
Mississippi River		64.355	103.569	Dale Gardner Veterans Memorial Bridge
				US 52 east / IL 64 east – Savanna	Continuation into Illinois
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Grant Wood Scenic Byway photo gallery
• Iowa 64 photo gallery