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KIF3B - Wikipedia

From Wikipedia, the free encyclopedia

KIF3B

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3B6U

Identifiers

Aliases

KIF3B, FLA8, HH0048, KLP-11, kinesin family member 3B, RP89

External IDs

OMIM: 603754; MGI: 107688; HomoloGene: 55849; GeneCards: KIF3B; OMA:KIF3B - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q11.21	Start	32,277,651 bp^[1]
Band	20q11.21	End	32,335,011 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 H1\|2 75.41 cM	Start	153,133,333 bp^[2]
Band	2 H1\|2 75.41 cM	End	153,175,310 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

islet of Langerhans

sperm

bronchial epithelial cell

renal medulla

jejunal mucosa

secondary oocyte

Brodmann area 23

Parietal Lobe

superior frontal gyrus

Top expressed in

spermatocyte

spermatid

seminiferous tubule

granulocyte

neural layer of retina

lumbar spinal ganglion

dentate gyrus of hippocampal formation granule cell

retinal pigment epithelium

primary visual cortex

superior frontal gyrus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding microtubule motor activity ATPase activity intraciliary transport particle B binding
Cellular component	cytoplasm intraciliary transport particle cytosol membrane microtubule cytoskeleton spindle plus-end kinesin complex midbody ciliary tip spindle microtubule extracellular exosome cytoskeleton microtubule axon cytoplasm centrosome kinesin II complex cell projection axon cilium kinesin complex
Biological process	plus-end-directed vesicle transport along microtubule antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic spindle organization anterograde axonal transport positive regulation of cytokinesis mitotic spindle assembly determination of left/right symmetry mitotic centrosome separation retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum microtubule-based movement intraciliary transport involved in cilium assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9371


16569

Ensembl


ENSG00000101350


ENSMUSG00000027475

UniProt


O15066


Q61771

RefSeq (mRNA)


NM_004798


NM_008444

RefSeq (protein)


NP_004789


NP_032470

Location (UCSC)

Chr 20: 32.28 – 32.34 Mb

Chr 2: 153.13 – 153.18 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.^[5]^[6] KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors.^[7] First, KIF3B forms a heterodimer with KIF3A (kinesin-like protein KIF3A); (KIF3A/3B), that is membrane-bound and has ATPase activity. Then KIFAP3 (KAP3, kinesin superfamily associated protein–3) binds to the tail domain to form a heterotrimeric motor.^[7] This motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ~0.3 μm/s a.^[8] There are 14 kinesin protein families in the kinesin superfamily and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes.^[9] Expression of the three motor subunits is ubiquitous. The KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles.^[7]

There are many orthologous KIF3B genes that are expressed in Drosophila, the sea urchin, Bos taurus, Canis familiaris, Equus caballus, Felis catus, Macaca mulatta, Mus musculus, Pan troglodytes, and Rattus norvegicus.

Function

The heterotrimeric KIF3B/KIF3A/KAP3 motor machinery functions in the intracellular transport of multiple different molecules such as β-catenin and MT1-MMP.^[10]^[11] KIF3B activity has been implicated with various cellular processes such as intracellular movement of organelles, intraflagellar transport, chromosome movement during mitosis and meiosis, and cellular interaction with the extracellular matrix.^[6]^[12]^[13]

KIF3B also regulates the interaction of cancer cells with the extracellular matrix (ECM), in particular the transport of MT1-MMP to the cancer cell front is essential for collagen fiber matrix realignment and degradation.^[14]^[15]

Interactions

KIF3B has been shown to interact with the SMC3 subunit of the cohesin complex and with RAB4A.^[16]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101350 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027475 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, et al. (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
^ ^a ^b "Entrez Gene: KIF3B kinesin family member 3B".
^ ^a ^b ^c Hirokawa N (January 1998). "Kinesin and dynein superfamily proteins and the mechanism of organelle transport". Science. 279 (5350): 519–26. Bibcode:1998Sci...279..519H. doi:10.1126/science.279.5350.519. PMID 9438838.
^ Hirokawa N (January 1998). "Kinesin and dynein superfamily proteins and the mechanism of organelle transport". Science. 279 (5350): 519–26. Bibcode:1998Sci...279..519H. doi:10.1126/science.279.5350.519. PMID 9438838.
^ Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, et al. (October 2004). "A standardized kinesin nomenclature". The Journal of Cell Biology. 167 (1): 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732.
^ Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T (April 2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nature Cell Biology. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492. S2CID 10745049.
^ Wiesner C, Faix J, Himmel M, Bentzien F, Linder S (September 2010). "KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages". Blood. 116 (9): 1559–69. doi:10.1182/blood-2009-12-257089. PMID 20505159.
^ Scholey JM (April 1996). "Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles". The Journal of Cell Biology. 133 (1): 1–4. doi:10.1083/jcb.133.1.1. PMC 2120781. PMID 8601599.
^ Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, et al. (October 2004). "A standardized kinesin nomenclature". The Journal of Cell Biology. 167 (1): 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732.
^ Kravtsov O, Hartley CP, Compérat EM, Iczkowski KA (2019). "KIF3B protein expression loss correlates with metastatic ability of prostate cancer". American Journal of Clinical and Experimental Urology. 7 (3): 178–181. PMC 6627541. PMID 31317057.
^ Stoletov K, Willetts L, Paproski RJ, Bond DJ, Raha S, Jovel J, et al. (June 2018). "Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis". Nature Communications. 9 (1): 2343. Bibcode:2018NatCo...9.2343S. doi:10.1038/s41467-018-04743-2. PMC 6002534. PMID 29904055.
^ Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM (July 2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin". Molecular and Cellular Biology. 23 (14): 4892–900. doi:10.1128/MCB.23.14.4892-4900.2003. PMC 162221. PMID 12832475.

Function

Interactions

References

Further reading