The Serie A has 36 teams (5 Liga de Expansión MX Reserve Teams and 31 Serie A Teams) divided into three groups. For the 2024–25 season, it will be a return of a short tournament format (Apertura & Clausura) consisting of 11 group matches and 3 inter-group matches (14 total) played home & away and the liguilla. The top two teams from each group and the two best third places at the end of the season will play in the Liguilla for a spot to play for promotion to Liga de Expansión MX provided that their stadiums meet the requirements to ascend.

The Serie A was created in the second half of 2008, with the participation and approval of the owners of the teams of the Second and Third Division, being next to Serie B part of the Liga Premier.

As of the 2024–25 Season, Atlético Morelia, Celaya, Correcaminos UAT, Mineros de Zacatecas and U. de G. all from Liga de Expansión MX will join the Liga Premier to give young players professional experience. However, only Correcaminos UAT and Leones Negros UdeG will have a reserve team, while Celaya, Atlético Morelia and Mineros de Zacatecas will have an associated team that will have its own identity.

The member clubs of the Serie A for the 2024–25 season are listed as follows.^[4]

Mexicali

Durango

Guasave

Los Cabos

Apodaca

Fresnillo

Cimarrones

UdeG

Tritones

Tecos

Álica

UAZ

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Location of teams in the 2024–25 Serie A Group 1

Club	Manager	City	Stadium	Capacity	Affiliate
Agricultores de Guasave	Christian Patiño	Guasave, Sinaloa	Armando "Kory" Leyson	9,000	–
Alacranes de Durango	Ricardo Rayas	Durango City, Durango	Francisco Zarco	18,000	–
Cimarrones de Sonora	Valentín Arredondo	Hermosillo, Sonora	Héroe de Nacozari	18,747	–
Leones Negros UdeG	Ricardo Jiménez	Zapopan, Jalisco	Instalaciones Club Deportivo U.de G. Cancha 3	3,000	Leones Negros UdeG
Los Cabos United	Edson Alvarado	Los Cabos, Baja California Sur	Complejo Don Koll	3,500	–
Mexicali	Omar Ramírez	Mexicali, Baja California	Ciudad Deportiva Mexicali	5,000	–
Mineros de Fresnillo	Isaac Martínez	Fresnillo, Zacatecas	Unidad Deportiva Minera Fresnillo	6,000	Mineros de Zacatecas
Real Apodaca	Omar Gómez	Apodaca, Nuevo León	Centenario del Ejército Mexicano	2,000	–
Tecos	Jorge Hernández	Zapopan, Jalisco	Tres de Marzo	18,779	–
Tigres de Álica	Hugo López (Interim)	Tepic, Nayarit	Nicolás Álvarez Ortega	12,495
Tritones Vallarta	Juan Pablo Alfaro	Bahía de Banderas, Nayarit	Ciudad del Deporte San José del Valle	4,000	–
Tuzos UAZ	Rubén Hernández	Zacatecas City, Zacatecas	Carlos Vega Villalba	20,068	–

Peribán

Uruapan

Salamanca

La Piedad

Lobos

Irapuato

Halcones

UAT

Canamy

Gavilanes

Colima

Zacatepec

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Location of teams in the 2024–25 Serie A Group 2

Club	Manager	City	Stadium	Capacity	Affiliate
Aguacateros CDU	Edgar Tolentino	Uruapan, Michoacán	Unidad Deportiva Hermanos López Rayón	6,000	Atlético Morelia
Aguacateros de Peribán	Marco Angúlo	Peribán, Michoacán	Municipal de Peribán	3,000	–
Colima	Sergio Bueno	Colima City, Colima	Colima	12,000	–
Gavilanes de Matamoros	Raúl Salazar	Matamoros, Tamaulipas	El Hogar	22,000	–
Halcones	Carlos Salcido	Querétaro City, Querétaro	Olímpico de Querétaro	4,600	–
Irapuato	Víctor Medina	Irapuato, Guanajuato	Sergio León Chávez	25,000	–
La Piedad	Arturo Espinoza (Interim)	La Piedad, Michoacán	Juan N. López	13,356	–
Lobos ULMX	Rowan Vargas	Celaya, Guanajuato	Miguel Alemán Valdés	23,182	Celaya[5]
Petroleros de Salamanca	Andrés Garza	Salamanca, Guanajuato	El Molinito	2,500	–
Sporting Canamy	Francisco Tena	Oaxtepec, Morelos	Olímpico de Oaxtepec	9,000	–
UAT	Jorge Dimas	Ciudad Victoria, Tamaulipas	Prof. Eugenio Alvizo Porras [a]	5,000	UAT
Zacatepec	Miguel Gutiérrez	Zacatepec, Morelos	Agustín "Coruco" Díaz	24,313	–

Acatlán

Aragón

Chilpancingo

Texcoco

Jaguares

Montañeses

Inter Playa

Pioneros

Veracruz

Tapachula

Venados

Zitácuaro

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Location of teams in the 2024–25 Serie A Group 3

Club	Manager	City	Stadium	Capacity	Affiliate
Acatlán[a]	José Casillas	Arandas, Jalisco	Unidad Deportiva Gustavo Díaz Ordaz	2,000	–
Atlético Aragón	Juan Carlos Moreno	Cuautitlán, State of Mexico	Los Pinos	5,000	–
Chilpancingo	Sebastián Lencina	Chilpancingo, Guerrero	General Vicente Guerrero	5,000	–
Deportiva Venados	Alfredo García Salmones	Tamanché, Yucatán	Alonso Diego Molina	2,500	–
Faraones de Texcoco	Vacant	Texcoco, State of Mexico	Estadio Municipal Claudio Suárez	5,000	–
Inter Playa del Carmen	Nicolás Burtovoy	Playa del Carmen, Quintana Roo	Unidad Deportiva Mario Villanueva Madrid	7,500	–
Jaguares	Alfredo Durán	Tuxtla Gutiérrez, Chiapas	Víctor Manuel Reyna	29,001	–
Montañeses	Vacant	Orizaba, Veracruz	Socum	7,000	–
Pioneros de Cancún	Víctor Téllez	Cancún, Quintana Roo	Cancún 86	6,390	Cancún[6]
Racing de Veracruz	Alejandro Pérez	Boca del Río, Veracruz	Unidad Deportiva Hugo Sánchez	1,200	–
Tapachula Soconusco	Carlos Gómez	Tapachula, Chiapas	Olímpico de Tapachula	18,017	–
Zitácuaro	Mario Alberto Trejo	Zitácuaro, Michoacán	Ignacio López Rayón	10,000	–

Club	Manager	City	Stadium	Capacity	Affiliate
Coras	Elias Mdahuar	Piedras Negras, Coahuila	Sección 123	6,000	–
Reynosa	Édgar Barrón	Reynosa, Tamaulipas	Unidad Deportiva Solidaridad	20,000	–
Yalmakán	Vacant	Chetumal, Quintana Roo	José López Portillo	6,600	–

• On May 11, 2024 Aguacateros CDU was promoted from Serie B to Serie A.^[7]
• On May 25, 2024 Acatlán was promoted from Liga TDP to Serie A.^[8]
• On May 26, 2024 Faraones de Texcoco was promoted from Liga TDP to Serie A.^[9]
• On June 17, 2024 Cimarrones de Sonora Premier was renamed to Cimarrones de Sonora because it became the club's main team after the beginning of the sale process of the team that played in Liga de Expansión MX.^[10]
• On June 28, 2024 Agricultores Guasave and Tapachula Soconusco joined the league as expansion teams.^[11][12]
• On June 28, 2024 Cafetaleros de Chiapas was renamed Jaguares F.C.^[13] Originally the team would be a reserve squad of a Liga de Expansión MX club,^[14] however on July 12, 2024 the project was rejected in the second tier of Mexican football, so finally Jaguares will compete in the Liga Premier – Serie A.^[15]
• On June 28, 2024 Racing Porto Palmeiras was renamed to Racing de Veracruz.^[16]
• On June 28, 2024 C.D. Avispones de Chilpancingo was promoted from Serie B to Serie A as an expansion team.^[17]
• On June 28, 2024 Tigres de Álica F.C. was promoted from Liga TDP to Serie A as an expansion team.^[18]
• On June 28, 2024 Calor and Saltillo were relocated to Serie B from Serie A.^[19]
• On June 28, 2024 Coras and Reynosa were put on hiatus.^[20]
• On June 28, 2024 the league format was modified, the two tournaments per season were reinstated after one year with a single-season tournament.^[21]
• On July 2, 2024 Halcones de Zapopan was renamed Halcones F.C.,^[22] in addition the team was relocated to Querétaro City.^[23]
• On July 12, 2024 Tampico Madero was accepted in the Liga de Expansión MX after winning promotion on May 25.^[24] Alacranes de Durango had also opted for the promotion, however, this team was rejected by the league owners assembly.^[15]
• On July 21, 2024 Escorpiones Zacatepec was rebranded Zacatepec F.C.^[25]
• On July 24, 2024 Zitácuaro was promoted from Serie B to Serie A as an expansion team.^[26]

Apertura Tournament

• After Week 5 Petroleros de Salamanca was moved to Estadio El Molinito, due to the fact that the club did not obtain permission to remain in the Estadio Sección XXIV, which had caused the team to play its first two home games at the facilities of the Mexican Football Federation, located in Toluca.^[27]
• Since Week 5 Acatlán F.C. was relocated to Arandas, Jalisco because the stadium registered by the team was damaged by heavy rains that occurred in the region where the club was located.^[28]