To be included in this list of Italian-American business people, individuals must have a Wikipedia article showing they are Italian-American business people, or must have other published references showing they are Italian-American business people and are notable.

• Frank Abagnale Jr., founder of Abagnale & Associates, a financial fraud consultancy company.
• Gil Amelio, former CEO of National Semiconductor and Apple
• William Amelio, president and CEO of Lenovo Group Limited
• Mark Attanasio, owner of the Milwaukee Brewers
• Joseph Baratta (1971-), Global Head of Private Equity at Blackstone
• Richard Belluzzo, computer industry executive at HP, SGI, Microsoft, Quantum
• Laurence Boschetto (1954-), senior advisor at The Interpublic Group of Companies
• John Brunetti, CEO of Hialeah Park Race Track
• Debra Cafaro, CEO of Ventas, Inc
• Jim Cantalupo (1943-2004), chairman and CEO of McDonald's
• Michael Capellas, CEO of First Data Corporation
• Chris Capossela (1969-), CMO and Executive Vice President of Consumer Business at Microsoft
• Leo Castelli, art trader
• Bob Castellini, owner of the Cincinnati Reds
• Sal DeVito, advertising executive at DeVito/Verdi
• Samuel DiPiazza, CEO of PricewaterhouseCoopers
• Carmine Di Sibio (1963-), Global Chairman and CEO of Ernst & Young
• Nick Donofrio, Executive Vice President of Innovation and Technology at the IBM Corporation
• Joe Gebbia, designer and Internet entrepreneur. He is a co-founder of Airbnb
• Domingo Ghirardelli, Italian-born chocolatier who was the founder of the Ghirardelli Chocolate Company in San Francisco, California.
• Richard Grasso (1946–), former chairman and CEO of the New York Stock Exchange
• Lee Iacocca (1924–2019), former chairman of the Chrysler Corporation
• Paul Montrone (1941-), Chairman and CEO of Fisher Scientific
• Tommy Mottola, Chairman and CEO of Sony Music Entertainment
• Angelo Mozilo, founder and CEO of Countrywide Financial
• Richard Nanula, CFO at Amgen and The Walt Disney Company
• Robert Nardelli, former chairman and CEO of Home Depot and Chrysler
• Frank Nuovo, head of design at Vertu
• Paul Otellini (1950–2017), Intel Corporation's fifth Chief Executive Officer
• Samuel J. Palmisano (1951–), chairman and CEO of IBM
• Frank P. Pellegrino (1901–1975), chairman and CEO of the International Hat Company
• Jerry Perenchio, former Chairman and CEO of Univision
• Joe J. Plumeri, chairman and CEO of Willis Group Holdings
• Roberto Quarta (1949-), chairman of Smith & Nephew and WPP plc
• Ed Rensi, President and CEO of McDonald's
• Aaron Russo, film producer
• Patricia Russo (1952–), CEO of Lucent Technologies
• Peter F. Secchia, former chairman and CEO of Universal Forest Products
• Joseph Trino, former chairman and CEO of SynQuest Inc
• Barbara Turf (1943–2014), CEO of Crate & Barrel
• Meggan Scavio, President and CEO of the Academy of Interactive Arts & Sciences (AIAS)
• Sonny Vaccaro (1939-), former sports marketing executive
• Linda Yaccarino, CEO of Twitter

• Charles Carmine Antonio Baldi (C.C.A. Baldi), (1862-1930), Philadelphia merchant, banker, newspaper publisher, entrepreneur and philanthropist
• Robert Benedetto (1946–), founder of Benedetto Guitars, Inc.
• Steve Bisciotti (1960–), billionaire founder of the Allegis Group, owner of the Baltimore Ravens
• Daniele Bodini (1945–), real estate entrepreneur, San Marino's former Ambassador to the United Nations
• Hector Boyardee, famous for his Chef Boyardee brand of food products
• Richard N. Cabela (1936-2014), co-founder of Cabela's
• Anthony Campagna (1884-1969), real estate developer
• Domenico Canale (1843–1919), founder of D. Canale & Co., major distributor of food and beverages
• Salvatore Capezio (1871–1940), founder of Capezio
• Henry Caruso (1922-2017), founder of Dollar Rent A Car
• Rick Caruso (1959-), founder of Caruso Affiliated
• Pat Croce (1954–), former owner of the Philadelphia 76ers basketball team
• Anthony Casalena, founder and CEO of Squarespace
• Ugo Colombo (1961-), founder of CMC Group
• Rocco B. Commisso (1949-), founder, chairman and CEO of Mediacom
• Carmine D'Addario, co-founder of D'Addario strings
• Nicholas D'Agostino, Sr. (1910–1996), co-founder of D'Agostino Supermarkets
• John D'Angelico (1905–1964), luthier from New York City, noted for his handmade archtop guitars
• Edward J. DeBartolo, Jr. (1946–), billionaire, former owner of the San Francisco 49ers
• John Paul DeJoria (1944–), co-founder of the Paul Mitchell line of hair products and The Patrón Spirits Company
• Remo Belli (1927–2016), jazz drummer who developed and marketed the first successful synthetic drumheads and founded the Remo company.
• Daniel A. D'Aniello (1946–), cofounder and chairman of the Carlyle Group
• Chris Deering (1947–), executive and marketer for Sony PlayStation and other video games^[1]
• Fred DeLuca, founder of Subway Sandwich
• Giorgio DeLuca, founder of Dean & DeLuca
• Pat DiCesare (1938-), concert promoter and founder of DiCesare Engler Productions
• Dante DiCicco (1988–), executive and head of international expansion for Snapchat
• Jack Dorsey (1976-), co-founder of Twitter, Inc. and Block, Inc.
• Philip Falcone (1962–), founder of Harbinger Capital and LightSquared
• Vincenzo Ferdinandi, designer among the founders of Italian Haute couture
• Frank Fertitta III, American casino executive and sports promoter, Ultimate Fighting Championship
• Lorenzo Fertitta, American casino executive and sports promoter, Ultimate Fighting Championship
• Tilman Fertitta (1957-), founder, president and CEO of Landry's
• Bill Gallo, founder of Columbia Grain Trading Inc. which he developed into the No. 1 supplier of soybeans to China
• Ernest Gallo, co-founder of the E & J Gallo Winery
• Joe Gebbia (1981–), co-founder of Airbnb
• Domingo Ghirardelli (1817–1894), founder of Ghirardelli Chocolate Company
• Giovanni Giotta (1920–2016), founder of Caffe Trieste of San Francisco)
• Tom Golisano (1941–), billionaire founder of Paychex, former owner of the Buffalo Sabres, three-time candidate for Governor of New York
• Vincent Gruppuso (1940-2007), founder of Kozy Shack Enterprises
• Arthur Edward Imperatore, Sr. (1925–2020), businessman from New Jersey, founder and president of NY Waterway ferry service
• Kenneth Langone (1935–), billionaire founder of The Home Depot
• Lani Lazzari, founder of cosmetics company Simple Sugars
• James Leprino (1937–), chairman of the world's largest manufacturer of mozzarella cheese, Leprino Foods
• Gennaro Lombardi, opened the first US pizzeria in 1905, Lombardi's
• Sam Lucchese (1868-1929), founder of the Lucchese Boot Company
• Joe Mansueto (1956–), founder, majority owner and executive chairman of Morningstar, Inc. and owner of Major League Soccer
• Domingo Marcucci (1827–1905) Venezuelan born shipbuilder and shipowner settled in San Francisco, California
• Giacomo Marini (born 1951), founder of Noventi, a technology venture capital firm, based in Silicon Valley. From 2013 to 2017 he was Chairman and CEO of Neato Robotics, a home robot company until its acquisition by Vorwerk
• Lelio Marino (1935–2004), co-founder of construction company Modern Continental
• Roger Marino, founder of EMC Corporation
• Vincent Marotta, founder of Jarden Corporation
• Robert Mondavi (1913–2008), leading vineyard operator in California's Napa Valley
• Bill Novelli co-founder of Porter Novelli
• Amedeo Obici (1877–1947), founder of the Planters Peanut Company in 1906
• Harry Olivieri (1916-2006), co-founder of the Pat's King of Steaks
• Carl Paladino, founder and chairman of Ellicott Development Co.
• James Pallotta (1958-), founder of the Raptor Group
• Don Panoz (1935–2018), founder of various pharmaceutical companies
• Antonio Pasin (1897–1990), was the founder of the Radio Flyer company in 1917
• Charles V. Paterno (1878-1946), real estate developer
• Jeno Paulucci (1918-2011), founder of Bellisio Foods
• Mario Peruzzi (1875–1955), co-founder of Planters Peanut Company in 1906
• Almerindo Portfolio (1877–1966), President of Bank of Sicily (USA), and Treasurer of New York City
• Leandro Rizzuto (1938–2017), chairman and co-founder of Conair Corporation
• Anthony T. Rossi (1900–1993), Italian immigrant who founded Tropicana Products
• Henry Salvatori (1901–1997), Italian immigrant geophysicist, businessman, philanthropist, and political activist who founded Western Geophysical
• Peter Santenello (born 1977), videomaker, traveler, and entrepreneur who produces videos about travel and human stories
• Jasper Sanfilippo (1931–2020), Illinois-based businessman, industrialist and philanthropist
• Franco Scalamandré (1898-1988), founder of Scalamandré Inc.
• John A. Sobrato (1939-), founder of the Cupertino, California-based Sobrato Organization, a Silicon Valley development firm specializing in commercial and residential real estate
• Vaccaro brothers, founders of Standard Fruit Company
• Donald Valle(1908–1977), founder and President of Valle's Steak House
• Joey Vento(1939–2011), founder of Geno's Steaks
• Andrew Viterbi (1935–), Italian immigrant founder of Qualcomm
• Mike Volpi, co-founder of Index Ventures
• Pierluigi Zappacosta (1950–), Italian immigrant founder of Logitech
• Marco Zappacosta (1985–), founder of Thumbtack
• Rocco B. Commisso (1949–), billionaire founder of Mediacom and current owner of New York Cosmos and ACF Fiorentina

• Robert Agostinelli (1953–), chairman and co-founder of private equity firm Rhône Group
• Ray Dalio (1949-), Founder of Bridgewater Associates
• Mario Gabelli (1942–), stock investor, investment adviser and financial analyst
• Amadeo Giannini (1870–1949), founder of Bank of Italy, which later became Bank of America, the largest bank in the United States
• Luigi Fugazy (1839-1930), banker
• Douglas Leone (1957-), venture capitalist and former managing partner of Sequoia Capital
• Joseph Perella (1941-), co-founder and CEO of Perella Weinberg Partners
• Frank Quattrone (1955–), investment banker who led dozens of major IPOs during the 1990s tech boom
• Lewis Ranieri (1947–), pioneer of mortgage-backed securities
• Chris Sacca (1975-), Founder of Lowercase Capital
• Vincent Viola (1956–), founder of Virtu Financial, one of the largest providers of financial services, trading products and market making services

• Nick Barrucci, founder, CEO and publisher of Dynamite Entertainment
• Carlo Barsotti (1850-1927), founder of Il Progresso Italo-Americano
• George T. Delacorte, Jr. (1894–1991), founder of Dell Publishing
• Bob Guccione (1930–2010), founder and former publisher of Penthouse Magazine
• Bob Guccione Jr. (1955-), founder the music magazine Spin
• Generoso Pope Jr. (1927-1988), founder of National Enquirer
• Leonard Riggio (1941–), owner of Barnes & Noble
• Louis Rossetto (1949–), founder and former publisher of Wired Magazine

• List of famous Italian-Americans