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  2. World Encyclopedia
  3. Mexedrone - Wikipedia
Mexedrone - Wikipedia
From Wikipedia, the free encyclopedia
Mexedrone
Legal status
Legal status
Identifiers
  • 3-Methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC12H17NO2
Molar mass207.273 g·mol−1
3D model (JSmol)
  • Cc1ccc(cc1)C(=O)C(COC)NC
  • InChI=1S/C12H17NO2/c1-9-4-6-10(7-5-9)12(14)11(13-2)8-15-3/h4-7,11,13H,8H2,1-3H3
  • Key:JHGDCSPZKQLBOP-UHFFFAOYSA-N

Mexedrone (also known as 4-MMC-MeO) is a stimulant and an entactogen drug of the cathinone class that has been sold online as a designer drug.[1][2][3][4] It is the alpha-methoxy derivative of Mephedrone.

Pharmacology

Mexedrone acts as a weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 5,289 nM, 8,869 nM, and 6,844 nM, respectively, as well as a weak serotonin releasing agent (SRA) with an EC50 value of 2,525 nM.[5]

Mexedrone is illegal in Sweden as of January 26, 2016[6] as well as Japan as of August 24, 2016.[7]

See also

References

  1. ^ "Mexedrone". New Synthetic Drug Database.
  2. ^ Qian Z, Jia W, Li T, Liu C, Hua Z (February 2017). "Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC". Drug Testing and Analysis. 9 (2): 274–281. doi:10.1002/dta.1983. PMID 27352812.
  3. ^ Kuś P, Rojkiewicz M, Kusz J, Książek M, Sochanik A (14 May 2019). "Spectroscopic characterization and crystal structures of four hydrochloride cathinones: N-ethyl-2-amino-1-phenylhexan-1-one (hexen, NEH), N-methyl-2-amino-1-(4-methylphenyl)-3-methoxypropan-1-one (mexedrone), N-ethyl-2-amino-1-(3,4-methylenedioxyphenyl)pentan-1-one (ephylone) and N-butyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-chlorobutylcathinone)". Forensic Toxicology. 37 (2): 456–464. doi:10.1007/s11419-019-00477-y. hdl:20.500.12128/9638.
  4. ^ Roberts L, Ford L, Patel N, Vale JA, Bradberry SM (March 2017). "11 analytically confirmed cases of mexedrone use among polydrug users". Clinical Toxicology. 55 (3): 181–186. doi:10.1080/15563650.2016.1271424. PMID 28075189. S2CID 33220365.
  5. ^ McLaughlin G, Morris N, Kavanagh PV, Power JD, Dowling G, Twamley B, et al. (March 2017). "Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone". Drug Testing and Analysis. 9 (3): 358–368. doi:10.1002/dta.2053. PMC 5336524. PMID 27524685.
  6. ^ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. November 2015.
  7. ^ "指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare.
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