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Myelocyte

Details
Precursor	Promyelocyte
Gives rise to	Metamyelocyte
Location	Bone marrow
Identifiers
TH	H2.00.04.3.04004
FMA	83525
Anatomical terms of microanatomy [edit on Wikidata]

A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases).

Structure

When stained with the usual dyes, the cytoplasm is distinctly basophilic and relatively more abundant than in myeloblasts or promyelocytes, even though myelocytes are smaller cells.

Numerous cytoplasmic granules are present in the more mature forms of myelocytes. Neutrophilic and eosinophilic granules are peroxidase-positive, while basophilic granules are not.

The nuclear chromatin is coarser than that observed in a promyelocyte, but it is relatively faintly stained and lacks a well-defined membrane.

The nucleus is fairly regular in contour (not indented), and seems to be 'buried' beneath the numerous cytoplasmic granules. (If the nucleus were indented, it would likely be a metamyelocyte.)

Measurement

There is an internationally agreed method of counting blasts, with results from M1 upwards.

Development

Promyelocyte → Myelocytes → metamyelocytes.

Additional images

Hematopoiesis

References

^ Histology image:01809loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01810loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01804loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.

External links

Neutrophilic Myelocyte Presented by the University of Virginia
Eosinophilic Myelocyte Presented by the University of Virginia
Basophilic Myelocyte Presented by the University of Virginia
Image at queensu.ca Archived 2007-08-27 at the Wayback Machine

Myeloid blood cells and plasma

Hematopoiesis

Myelopoiesis
(CFU-GEMM)

CFU-GM

Granulopoiesis Myeloblast Promyelocyte Myelocyte Metamyelocyte Band cell
Monocytopoiesis Monoblast Promonocyte

MEP

Thrombopoiesis Megakaryoblast Promegakaryocyte
Erythropoiesis Proerythroblast Normoblast Reticulocyte

General

Extramedullary hematopoiesis

Myeloid tissue

Granulocytes

Monocytes

Macrophages	Histiocytes Kupffer cells Alveolar macrophage Microglia Osteoclasts Epithelioid cells giant cells Langhans giant cells Foreign-body giant cell Touton giant cells
Other	Antigen-presenting cells Dendritic cells Langerhans cell CFU-DL Monoblast MPS

Platelets

Red blood cells

Immune response

Other

Precursor cells
Myelomonocyte