Nuestra Belleza Sinaloa 2012, was held at the Modular Inés Arredondo of Culiacán, Sinaloa on June 22, 2012. At the conclusion of the final night of competition, Karime Macías from Mazatlán was crowned the winner. Macías was crowned by outgoing Nuestra Belleza Sinaloa titleholder, Grecia Gutiérrez. Eight contestants competed for the title.