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OXR1

Identifiers

OXR1, TLDC3, Nbla00307, oxidation resistance 1, CHEGDD

External IDs

OMIM: 605609; MGI: 2179326; HomoloGene: 24993; GeneCards: OXR1; OMA:OXR1 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q23.1	Start	106,270,144 bp^[1]
Band	8q23.1	End	106,752,694 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 B3.1	Start	41,310,878 bp^[2]
Band	15\|15 B3.1	End	41,724,444 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pons

Achilles tendon

lateral nuclear group of thalamus

trigeminal ganglion

sperm

spinal ganglia

seminal vesicula

Brodmann area 23

corpus epididymis

prefrontal cortex

Top expressed in

medial dorsal nucleus

parotid gland

subiculum

pontine nuclei

primary motor cortex

habenula

medial geniculate nucleus

lobe of cerebellum

cerebellar vermis

inferior colliculi

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity protein binding molecular function
Cellular component	nucleolus mitochondrion cellular component nucleoplasm intracellular membrane-bounded organelle
Biological process	negative regulation of neuron apoptotic process response to oxidative stress cellular response to hydroperoxide adult walking behavior neuron apoptotic process negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55074


170719

Ensembl


ENSG00000164830


ENSMUSG00000022307

UniProt


Q8N573


Q4KMM3

RefSeq (mRNA)

NM_001198532 NM_001198533 NM_001198534 NM_001198535 NM_018002
NM_181354

NM_001130163 NM_001130164 NM_001130165 NM_001130166 NM_130885
NM_001358976 NM_001358977 NM_001358978

RefSeq (protein)

NP_001185461 NP_001185462 NP_001185463 NP_001185464 NP_060472
NP_851999

NP_001123635 NP_001123636 NP_001123637 NP_001123638 NP_570955
NP_001345905 NP_001345906 NP_001345907

Location (UCSC)

Chr 8: 106.27 – 106.75 Mb

Chr 15: 41.31 – 41.72 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Oxidation resistance protein 1 is a protein that in humans is encoded by the OXR1 gene.^[5]^[6] Loss of OXR1 function causes decline of the retromer complex.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164830 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022307 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Volkert MR, Elliott NA, Housman DE (Jan 2001). "Functional genomics reveals a family of eukaryotic oxidation protection genes". Proc Natl Acad Sci U S A. 97 (26): 14530–5. doi:10.1073/pnas.260495897. PMC 18953. PMID 11114193.
^ "Entrez Gene: OXR1 oxidation resistance 1".
^ Wilson KA, Bar S, et al. (Jan 2024). "OXR1 maintains the retromer to delay brain aging under dietary restriction". Nature Communications. 15 (1): 467. Bibcode:2024NatCo..15..467W. doi:10.1038/s41467-023-44343-3. PMC 10784588. PMID 38212606.

References

Further reading