PL-6983

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PL-6983
Clinical data
Routes of administration	Subcutaneous injection
Drug class	Melanocortin MC₄ receptor agonist
Identifiers
CAS Number	1966957-74-3
PubChem SID	472219121

PL-6983 is a synthetic peptide and selective MC₄ receptor agonist which is under development by Palatin Technologies for the treatment of female sexual dysfunction and erectile dysfunction.^[1]^[2] It was developed as a successor to/replacement of bremelanotide (PT-141) due to concerns of the side effect of increased blood pressure seen with the latter in clinical trials.^[1]^[2] Relative to bremelanotide, PL-6983 produces significantly lower increases in blood pressure in animal models.^[1]^[2] The drug has reportedly been in pre-clinical development for all medical indications since 2008.^[3] Palatin has stated that "We are focusing development efforts on bremelanotide for [female sexual dysfunction], but are continuing evaluation of PL-6983."^[4] The chemical structure of PL-6983 has yet to be made public.

References

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^ ^a ^b ^c Simon JA (July 2009). Mitchner N (ed.). "Opportunities for intervention in HSDD" (PDF). The Journal of Family Practice. 58 (7 Suppl Hypoactive): S26–30. PMID 19825316. Archived from the original (PDF) on 2015-05-18. Retrieved 2015-05-14.
^ ^a ^b ^c Krychman ML, Finestone S (25 October 2010). 100 Questions & Answers About Breast Cancer Sensuality, Sexuality and Intimacy. Jones & Bartlett Publishers. pp. 120–. ISBN 978-1-4496-1936-7.
^ "Research programme: sexual dysfunction therapy - Palatin Technologies". AdisInsight. Springer Nature Switzerland AG. Retrieved 2019-06-06.
^ "Palatin Technologies - PL-6983 for Female Sexual Dysfunction". 2015-05-26. Archived from the original on 2015-05-26.

External links

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v t e Sexual dysfunction pharmacotherapies
Dopamine agonists	Apomorphine Cabergoline Lisuride Pergolide Piribedil Pramipexole Quinagolide Ropinirole Rotigotine Terguride
Melanocortin agonists	Bremelanotide Melanotan II PL-6983
PDE5 inhibitors	Acetildenafil Aildenafil Avanafil Icariin Lodenafil Mirodenafil Nitrosoprodenafil Sildenafil Sulfoaildenafil Tadalafil Udenafil Vardenafil
Sex steroids	Androgens (e.g., testosterone, methyltestosterone, other anabolic steroids) Estrogens (e.g., estradiol, ethinylestradiol, conjugated equine estrogens (Premarin)) Progestogens (e.g., progesterone, progestins) Mixed (e.g., tibolone)
Others	Afrodor (acecarbromal, quebracho, vitamin E) Alkyl nitrites Alprostadil Amantadine Bupropion Buspirone Cyproheptadine Dapoxetine Flibanserin Mirtazapine Moxisylyte Oxytocin Papaverine Phentolamine Psychostimulants (e.g., amphetamines, cocaine, methylphenidate) Rauwolscine (Rauvolfia) Trazodone Yohimbine (Yohimbe)
See also: Drugs for erectile dysfunction and premature ejaculation

v t e Melanocortin receptor modulators
MC₁	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) BMS-470539 Bremelanotide HS-014 HS-024 MSH (α, β, γ) Melanotan II Modimelanotide PL-8177 SHU-8914 SHU-9005 SHU-9119 SNAP-7941 Antagonists: ASIP
MC₂	Agonists: ACTH (corticotropin) Alsactide Codactide Giractide Norleusactide (pentacosactride) Seractide Tetracosactide (tetracosactrin, cosyntropin) Tosactide (octacosactrin) Tricosactide Tridecactide
MC₃	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) Bremelanotide MSH (α, β, γ) Melanotan II Modimelanotide PG-931 Antagonists: AGRP ASIP HS-014 ML-00253764 PG-106 SHU-8914 SHU-9005 SHU-9119
MC₄	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) AZD2820 BIM-22493 Bremelanotide LY-2112688 MSH (α, β, γ) Melanotan II MK-0493 Modimelanotide PF-00446687 PG-931 PL-6983 Ro 27-3225 Setmelanotide THIQ Antagonists: AGRP ASIP HS-014 HS-024 HS-131 JKC-363 MCL-0020 MCL-0042 MCL-0129 ML-00253764 MPB-10 SHU-8914 SHU-9005 SHU-9119 Unknown: Semax
MC₅	Agonists: ACTH (corticotropin) Afamelanotide (melanotan I) Bremelanotide HS-014 HS-024 MSH (α, β, γ) Melanotan II Modimelanotide SHU-8914 SHU-9005 SHU-9119 Antagonists: ASIP ML-00253764 Unknown: Semax
Unsorted	Agonists: Alsactide Codactide Dersimelagon Giractide Norleusactide (pentacosactride) Seractide Tetracosactide (tetracosactrin, cosyntropin) Tosactide (octacosactrin) Tricosactide Tridecactide
Others	Propeptides: Lipotropin (β, γ) N-POMC (NPP, pro-γ-MSH) Proopiomelanocortin (POMC)

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See also

References

External links