From Wikipedia, the free encyclopedia
phosphonate dehydrogenase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 1.20.1.1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, a phosphonate dehydrogenase (EC 1.20.1.1) is an enzyme that catalyzes the chemical reaction
- phosphonate + NAD+ + H2O phosphate + NADH + H+
The 3 substrates of this enzyme are phosphonate, NAD+, and H2O, whereas its 3 products are phosphate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phosphonate:NAD+ oxidoreductase. Other names in common use include NAD:phosphite oxidoreductase, and phosphite dehydrogenase.
References
[edit]- Costas AM, White AK, Metcalf WW (2001). "Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88". J. Biol. Chem. 276 (20): 17429–36. doi:10.1074/jbc.M011764200. PMID 11278981.
- Vrtis JM, White AK, Metcalf WW, van der Donk WA (2001). "Phosphite dehydrogenase: an unusual phosphoryl transfer reaction". J. Am. Chem. Soc. 123 (11): 2672–3. doi:10.1021/ja004301k. PMID 11456941.
Other oxidoreductases (EC 1.15–1.21) | |
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1.15: Acting on superoxide as acceptor | |
1.16: Oxidizing metal ions | |
1.17: Acting on CH or CH2 groups | |
1.18: Acting on iron–sulfur proteins as donors | |
1.19: Acting on reduced flavodoxin as donor | |
1.20: Acting on phosphorus or arsenic in donors | |
1.21: Acting on X-H and Y-H to form an X-Y bond |
Activity | |
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Regulation | |
Classification | |
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