Progesterone 11alpha-monooxygenase

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progesterone 11-alpha-monooxygenase

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In enzymology, a progesterone 11alpha-monooxygenase (EC 1.14.99.14) is an enzyme that catalyzes the chemical reaction

progesterone + AH₂ + O₂

\rightleftharpoons

11alpha-hydroxyprogesterone + A + H₂O

The 3 substrates of this enzyme are progesterone, AH2, and O₂, whereas its 3 products are 11alpha-hydroxyprogesterone, A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating). This enzyme is also called progesterone 11alpha-hydroxylase. This enzyme participates in c21-steroid hormone metabolism.

References

Shibahara M, Moody JA, Smith LL (1970). "Microbial hydroxylations. V. 11-alpha-hydroxylation of progesterone by cell-free preparations of Aspergillus ochraceus". Biochim. Biophys. Acta. 202 (1): 172–9. doi:10.1016/0005-2760(70)90228-6. PMID 5417182.

v t e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate	Prolyl hydroxylase HIF prolyl-hydroxylase EGLN1 EGLN2 EGLN3 P4HTM Lysyl hydroxylase AlkB ALKBH1 FTO
1.14.13: NADH or NADPH	Flavin-containing monooxygenase FMO1 FMO2 FMO3 FMO4 FMO5 Nitric oxide synthase NOS1 NOS2 NOS3 Cholesterol 7 alpha-hydroxylase Methane monooxygenase 3A4 14α-demethylase 24-hydroxycholesterol 7α-hydroxylase
1.14.14: reduced flavin or flavoprotein	19A1 2D6 2E1
1.14.15: reduced iron–sulfur protein	11B1 11B2 11A1
1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase Tyrosine hydroxylase Tryptophan hydroxylase
1.14.17: reduced ascorbate	Dopamine beta-hydroxylase
1.14.18-19: other	Tyrosinase Stearoyl-CoA desaturase-1
1.14.99 - miscellaneous	Cyclooxygenase Heme oxygenase (HMOX1) Squalene monooxygenase 17A1 21A2 Ecdysone 20-monooxygenase Deoxyhypusine monooxygenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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