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Proteinase 3 - Wikipedia

From Wikipedia, the free encyclopedia

PRTN3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1FUJ

Identifiers

Aliases

PRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3

External IDs

OMIM: 177020; MGI: 893580; HomoloGene: 120934; GeneCards: PRTN3; OMA:PRTN3 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	840,999 bp^[1]
Band	19p13.3	End	848,175 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 C1\|10 39.72 cM	Start	79,710,310 bp^[2]
Band	10 C1\|10 39.72 cM	End	79,719,008 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bone marrow

bone marrow cells

spleen

blood

monocyte

granulocyte

right lung

superior frontal gyrus

right frontal lobe

dorsolateral prefrontal cortex

Top expressed in

tibiofemoral joint

granulocyte

fetal liver hematopoietic progenitor cell

body of femur

bone marrow

ankle joint

blastocyst

embryo

human fetus

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	enzyme binding peptidase activity serine-type peptidase activity hydrolase activity protein binding serine-type endopeptidase activity signaling receptor binding
Cellular component	extracellular matrix plasma membrane extracellular exosome cytosol extracellular region extracellular space azurophil granule lumen plasma membrane raft membrane membrane raft collagen-containing extracellular matrix
Biological process	collagen catabolic process blood coagulation negative regulation of phagocytosis mature conventional dendritic cell differentiation positive regulation of cell population proliferation antimicrobial humoral response neutrophil degranulation proteolysis membrane protein ectodomain proteolysis positive regulation of GTPase activity cell-cell junction maintenance neutrophil extravasation phagocytosis cytokine-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5657


19152

Ensembl


ENSG00000277804 ENSG00000196415


ENSMUSG00000057729

UniProt


P24158


Q61096

RefSeq (mRNA)


NM_002777


NM_011178

RefSeq (protein)


NP_002768


NP_035308

Location (UCSC)

Chr 19: 0.84 – 0.85 Mb

Chr 10: 79.71 – 79.72 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene.^[5]

Function

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.^[6]

References

^ ^a ^b ^c ENSG00000196415 GRCh38: Ensembl release 89: ENSG00000277804, ENSG00000196415 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057729 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". The Journal of Experimental Medicine. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764. PMID 2258701.
^ Hilhorst M, van Paassen P, Tervaert JW (October 2015). "Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis". Journal of the American Society of Nephrology. 26 (10): 2314–27. doi:10.1681/ASN.2014090903. PMC 4587702. PMID 25956510.

External links

Proteinase+3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e PDB gallery
1fuj: PR3 (MYELOBLASTIN)

Contents of the granules of granulocytes

Azurophilic granules (1°)

Myeloperoxidase
Defensins
neutral serine proteases (Proteinase 3)
Lysozyme
Bactericidal permeability-increasing protein
Collagenase

Specific granules (2°)

Neutrophil	Alkaline phosphatase Lactoferrin Lysozyme NADPH oxidase Collagenase Cathelicidin
Eosinophil	Cathepsin Major basic protein Eosinophil cationic protein Eosinophil peroxidase Eosinophil-derived neurotoxin
Basophil	Heparin Histamine

see also platelet alpha-granule, dense granule

v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Categories:

Hidden categories:

Function

References

Further reading

External links