Salivary duct carcinoma

From Wikipedia, the free encyclopedia

Salivary duct carcinoma

Low magnification micrograph of a salivary duct carcinoma with characteristic comedonecrosis (left of image) adjacent to normal parotid gland (right of image). H&E stain.
Specialty	ENT surgery

Salivary duct carcinoma (SDC) is a rare type of aggressive cancer that arises from the salivary glands.^[1] It is predominantly seen in men and, generally, has a poor prognosis.^[2] Other high grade carcinomas can mimic SDC. About 40-60% of SDC arise in pleomorphic adenomas.^[3] Most, if not all, SDCs express androgen receptor by immunohistochemistry.^[4] Therapeutically relevant genetic alterations include ERBB2/Her2 amplification, PIK3CA and/or HRAS mutations.^[5]^[6]

Signs and symptoms

The typical presentation is a rapidly growing mass with associated pain.^[2] This may be seen in association with neck lymph node swelling (cervical lymphadenopathy), due to metastases, and facial nerve paralysis.

Diagnosis

SDC are diagnosed by examination of tissue, e.g. a biopsy.

Their histologic appearance is similar to ductal breast carcinoma.

Very low mag.
Intermed. mag.
Very high mag.

References

^ Kinnera VS, Mandyam KR, Chowhan AK, Nandyala R, Bobbidi VP, Vutukuru VR (July 2009). "Salivary duct carcinoma of parotid gland". Journal of Oral and Maxillofacial Pathology. 13 (2): 85–88. doi:10.4103/0973-029x.57676. PMC 3162867. PMID 21887008.
^ ^a ^b Rajesh NG, Prayaga AK, Sundaram C (2011). "Salivary duct carcinoma: correlation of morphologic features by fine needle aspiration cytology and histopathology". Indian Journal of Pathology & Microbiology. 54 (1): 37–41. doi:10.4103/0377-4929.77321. PMID 21393874.
^ Chiosea SI, Thompson LD, Weinreb I, Bauman JE, Mahaffey AM, Miller C, et al. (October 2016). "Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations". Cancer. 122 (20): 3136–3144. doi:10.1002/cncr.30179. PMC 5048512. PMID 27379604.
^ Williams L, Thompson LD, Seethala RR, Weinreb I, Assaad AM, Tuluc M, et al. (May 2015). "Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression". The American Journal of Surgical Pathology. 39 (5): 705–713. doi:10.1097/pas.0000000000000413. PMID 25871467. S2CID 24737257.
^ Chiosea SI, Williams L, Griffith CC, Thompson LD, Weinreb I, Bauman JE, et al. (June 2015). "Molecular characterization of apocrine salivary duct carcinoma". The American Journal of Surgical Pathology. 39 (6): 744–752. doi:10.1097/pas.0000000000000410. PMID 25723113. S2CID 34106002.
^ Nardi V, Sadow PM, Juric D, Zhao D, Cosper AK, Bergethon K, et al. (January 2013). "Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment". Clinical Cancer Research. 19 (2): 480–490. doi:10.1158/1078-0432.ccr-12-1842. PMID 23186780.

External links

Tumors of lip, oral cavity and pharynx / head and neck cancer

Oral cancer

Salivary gland

malignant epithelial tumors	Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma Salivary duct carcinoma Epithelial-myoepithelial carcinoma Polymorphous low-grade adenocarcinoma Hyalinizing clear cell carcinoma
benign epithelial tumors	Pleomorphic adenoma Warthin's tumor
ungrouped	Oncocytoma

Tongue

Oropharynx

Category:

Salivary gland neoplasia

Hidden categories:

Signs and symptoms

Diagnosis

See also

References

External links