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Spectrum 10K is a paused study of autistic people intended to be the largest of its kind in the United Kingdom. The name refers to the autism spectrum and the putative number of subjects. Led by Simon Baron-Cohen under the aegis of the Autism Research Centre (ARC), the study (an outgrowth of the defunct Human Genome Project) included researchers at the University of Cambridge, the Wellcome Sanger Institute, and the University of California at Los Angeles (UCLA).^[1] Participants (including adults and minors with parental consent) were asked to contribute their DNA samples via swabs of saliva,^[2] as well as information on their overall mental and physical health. Overall, 10,000 autistic people and their families were to be involved in the study, which aimed to study genetic and environmental factors contributing to autism and co-occurring conditions.^[3]

Reaction

The project, which is anticipated to run for a decade,^[4] was controversial from the outset, in part, because the study was led by Baron-Cohen, who had previously criticised by some autistic people due to a proposed "extreme male brain" theory of autism.^[3] Additionally, many in the autism rights movement have criticised the lack of consultation with autistic people or their families,^[3] and raised privacy, scientific ethics and eugenics concerns due to fears of sharing genetic data.^[5]^[6]^[7] This led to the formation of the autistic-led Boycott Spectrum 10K group^[8] and hashtag,^[9] as well as a Change.org petition against the project. As a result of the backlash, the project was paused on 27 September 2021.^[3] However, autistic self-advocacy groups have continued to picket centres involved in the project.^[9]

As a result of the protest, a second ethics review was conducted. The second ethics review found that the first ethics review was correctly decided and that the study should continue.^[10]

References

^ "10,000 autistic people to take part in the UK's largest study of autism". University of Cambridge. August 24, 2021.
^ "ARC Volunteers - Spectrum 10K". parent.spectrum10k.org.
^ ^a ^b ^c ^d Sanderson, Katharine (27 September 2021). "High-profile autism genetics project paused amid backlash". Nature. 598 (7879): 17–18. Bibcode:2021Natur.598...17S. doi:10.1038/d41586-021-02602-7. PMID 34580484. S2CID 238202946.
^ "Spectrum 10K". Health Research Authority.
^ "Why Autistic People Are Worried by Spectrum 10K | Psychology Today United Kingdom". www.psychologytoday.com.
^ Rubino, Sebastian (August 29, 2021). "Spectrum 10k: The Fallacy of Genetic Autism Studies".
^ "What is the Spectrum 10K study into autism - and why are autistic people concerned?". www.indy100.com. August 29, 2021.
^ "PLAIN TEXT OF THE FULL BOYCOTT S10K STATEMENT". September 4, 2021.
^ ^a ^b Pring, John (4 November 2021). "Autistic campaigners' anger over Spectrum 10K protest lock-out and 'scare tactics'". Disability News Service.
^ Dattaro, Laura (2022-05-27). "Spectrum 10K gets green light from ethics agency". Spectrum. doi:10.53053/OAMY4481. S2CID 249143253. Retrieved 2022-12-08.

External links

Spectrum 10K – The largest study of autism in the UK Official website

Library resources about
Spectrum 10K

v t e Autism
Main	Causes Diagnosis Epidemiology Epigenetics Heritability History Memory Pathophysiology Sex and gender Societal and cultural aspects Therapies
Diagnoses	Pervasive developmental disorder Autistic disorder Asperger syndrome Pervasive developmental disorder not otherwise specified Childhood disintegrative disorder High-functioning autism
Associated conditions and phenomena	Alexithymia Autism and LGBTQ identities Autistic burnout Autistic catatonia Autistic masking Autistic meltdown Echolalia Echopraxia Emotional dysregulation Hyperlexia Infodumping Late talker Monotropism Nonverbal autism Pathological demand avoidance Pronoun reversal Savant syndrome Special interests Stimming Sensory overload
Comorbid conditions	Avoidant/restrictive food intake disorder Attention deficit hyperactivity disorder Anxiety disorder obsessive–compulsive disorder Developmental coordination disorder Epilepsy Intellectual disability Sensory processing disorder Global developmental delay Developmental verbal dyspraxia
Associated syndromes	22q13 deletion syndrome Angelman syndrome CHARGE syndrome Cohen syndrome Cornelia de Lange syndrome DiGeorge syndrome Down syndrome Fetal valproate spectrum disorder Fragile X syndrome MECP2 duplication syndrome Neurofibromatosis type I Noonan syndrome Multiple hamartoma syndrome Rett syndrome Smith–Lemli–Opitz syndrome Timothy syndrome Tuberous sclerosis Williams syndrome
Related issues	Autism rights movement Critical autism studies Discrimination Double empathy problem Employment Multiple complex developmental disorder Neurodiversity TEACCH program Twice exceptional Violence and autism
Controversies	Facilitated communication Lancet MMR autism fraud MMR vaccine Rapid prompting method Thiomersal Chelation Combating Autism Act Autistic supremacism
Diagnostic scales	Autism Diagnostic Interview Autism Diagnostic Observation Schedule Childhood Autism Rating Scale Gilliam Asperger's disorder scale
Screening scales	Autism-spectrum quotient Childhood Autism Spectrum Test Ritvo Autism and Asperger Diagnostic Scale
Lists	Autism-related topics Fictional characters Schools
Accommodations	Autism-friendly Sensory friendly
Category

Mental disorders (Classification)

Adult personality and behavior

Sexual	Ego-dystonic sexual orientation Paraphilia Fetishism Voyeurism Sexual anhedonia Sexual anorexia Sexual maturation disorder Sexual relationship disorder
Other	Factitious disorder Munchausen syndrome Fear of intimacy Gender dysphoria Intermittent explosive disorder Dermatillomania Kleptomania Pyromania Trichotillomania Personality disorder

Childhood and learning

Emotional and behavioral	ADHD Conduct disorder ODD Emotional and behavioral disorders Separation anxiety disorder Movement disorders Stereotypic Social functioning DAD RAD Selective mutism Speech Cluttering Stuttering Tic disorder Tourette syndrome
Intellectual disability	X-linked intellectual disability Lujan–Fryns syndrome
Psychological development (developmental disabilities)	Pervasive Specific

Mood (affective)
Bipolar Bipolar I Bipolar II Bipolar NOS Cyclothymia Depression Atypical depression Dysthymia Major depressive disorder Melancholic depression Seasonal affective disorder Mania

Neurological and symptomatic

Autism spectrum	Autism Asperger syndrome High-functioning autism PDD-NOS Savant syndrome
Dementia	AIDS dementia complex Alzheimer's disease Creutzfeldt–Jakob disease Frontotemporal dementia Huntington's disease Mild cognitive impairment Parkinson's disease Pick's disease Sundowning Vascular dementia Wandering
Other	Delirium Organic brain syndrome Post-concussion syndrome

Neurotic, stress-related and somatoform

Adjustment

Adjustment disorder with depressed mood

Anxiety

Phobia	Agoraphobia Childhood phobia Social anxiety Social phobia Anthropophobia Specific social phobia Specific phobia Claustrophobia
Other	Generalized anxiety disorder OCD Panic attack Panic disorder Stress Acute stress reaction PTSD

Dissociative

Somatic symptom

Physiological and physical behavior

Eating	Anorexia nervosa Bulimia nervosa Rumination syndrome Other specified feeding or eating disorder
Nonorganic sleep	Hypersomnia Insomnia Parasomnia Night terror Nightmare REM sleep behavior disorder
Postnatal	Postpartum depression Postpartum psychosis
Sexual desire	Hypersexuality Hypoactive sexual desire disorder

Psychoactive substances, substance abuse and substance-related
Drug overdose Intoxication Physical dependence Rebound effect Stimulant psychosis Substance dependence Withdrawal

Schizophrenia, schizotypal and delusional

Delusional	Delusional disorder Folie à deux
Psychosis and schizophrenia-like	Brief reactive psychosis Schizoaffective disorder Schizophreniform disorder
Schizophrenia	Childhood schizophrenia Disorganized (hebephrenic) schizophrenia Pseudoneurotic schizophrenia Simple-type schizophrenia
Other	Catatonia

Symptoms and uncategorized
Impulse-control disorder Klüver–Bucy syndrome Psychomotor agitation Stereotypy

Autism resources

Autism
- outline
- history

Awareness

Culture

Accommodations

Therapies

Psychotropic medication (antipsychotics)	Aripiprazole Risperidone
Behavioral	Discrete trial training (Lovaas) Picture exchange communication system (PECS) Pivotal response treatment Positive behavior support Early Start Denver Model (ESDM) Cognitive behavioral therapy (CBT) Social skills training
Developmental	Floortime (PLAY Project)
Controversial	Applied behavior analysis (ABA) Auditory integration training Aversion therapy (Judge Rotenberg Center) Chelation of mercury Facilitated communication Gluten-free, casein-free diet Hug machine Hyperbaric oxygen therapy Holding therapy Relationship development intervention Secretin Sensory integration therapy Son-Rise Vitamin B12
Related	ADHD medication Melatonin Occupational therapy Social Stories Speech therapy Selective serotonin reuptake inhibitors Structured teaching (TEACCH)

Centers

Research

United States	Association for Science in Autism Treatment Autism Research Institute Autism Science Foundation Kennedy Krieger Institute National Alliance for Autism Research Simons Foundation Autism Research Initiative Yale Child Study Center
United Kingdom	Autism Research Centre (UK)
Conditions and research areas Researchers

Therapy

United States	Center for Autism and Related Disorders (CARD) MIND Institute

Schools

Organizations

International

Americas

United States

Centro Ann Sullivan (Peru)
Domus Instituto de Autismo (Mexico)

Asia

Action for Autism (India)
Autism Resource Centre (Singapore)

Caribbean

Autistic Society of Trinidad and Tobago (Trinidad and Tobago)
Maia Chung Autism and Disabilities Foundation (Jamaica)

Europe

UK	Autism Anglia The Autism Directory Autism Awareness Campaign UK Autism Cymru Autism Plus Autistica National Autistic Society Sacar
Specialisterne (Denmark) Aspies For Freedom

Oceania

Luke Priddis Foundation (Australia)

Literature

Non-fiction	The Accidental Teacher: Life Lessons from My Silent Son Animals in Translation Aspergirls: Empowering Females with Asperger's Syndrome Autism's False Prophets Extreme Love: Autism Freaks, Geeks, and Asperger Syndrome: A User Guide to Adolescence In a Different Key Life, Animated Like Colour to the Blind Look Me in the Eye Mother Warriors My Autobiography NeuroTribes Nobody Nowhere The Reason I Jump Somebody Somewhere Son-Rise: The Miracle Continues Strange Son Switched On Unstrange Minds
Fiction	The Curious Incident of the Dog in the Night-Time Dear John House Rules Mockingbird Saving Max Speed of Dark The Winter Journey With the Light
For younger people	Everybody Is Different: A Book for Young People Who Have Brothers or Sisters With Autism Ian's Walk: A Story about Autism Marcelo in the Real World Rage: A Love Story Rules
Journals	Autism Autism in Adulthood Autism Research Journal of Autism and Developmental Disorders Molecular Autism Research in Autism Spectrum Disorders

Categories:

Hidden categories:

Classification	D ICD-11: 6A02 ICD-10: F84.0 ICD-9-CM: 299.00 OMIM: 209850 MeSH: D001321 DiseasesDB: 1142
External resources	MedlinePlus: 001526 eMedicine: med/3202 ped/180 GeneReviews: Autism overview