Strobilurins are a group of natural products and their synthetic analogs. A number of strobilurins are used in agriculture as fungicides. They are part of the larger group of Q_oIs (Quinone outside Inhibitors), which act to inhibit the respiratory chain at the level of Complex III.

The first parent natural products, strobilurins A and B, were extracted from the fungus Strobilurus tenacellus.^[1] Commercial strobilurin fungicides^[2] were developed through optimization of photostability and activity.^[3] Strobilurins represented a major development in fungus-based fungicides. First released in 1996, there are now ten major strobilurin fungicides on the market, which account for 23-25 % of the global fungicide sales.^[4] Examples of commercialized strobilurin derivatives are azoxystrobin, kresoxim-methyl, picoxystrobin, fluoxastrobin, oryzastrobin, dimoxystrobin, pyraclostrobin and trifloxystrobin.

Strobilurins are mostly contact fungicides with a long half time as they are absorbed into the cuticle and not transported any further. They have a suppressive effect on other fungi, reducing competition for nutrients; they inhibit electron transfer in mitochondria, disrupting metabolism and preventing growth of the target fungi.^[5]

Strobilurin A (also known as mucidin) is produced by Oudemansiella mucida, Strobilurus tenacellus, Bolinea lutea, and others.^[6][7][8] When first isolated it was incorrectly assigned as the E E E geometric isomer but was later identified by total synthesis as being the E Z E isomer, as shown.^[5]: 694

9-Methoxystrobilurin A is produced by Favolaschia spp.^[7]

Strobilurin B is produced by S. tenacellus.^[7]

Strobilurin C is produced by X. longipes and X. melanotricha.^[7][8]

Strobilurin D is produced by Cyphellopsis anomala.^[8] Its structure was originally incorrectly assigned and is now considered to be identical to that of strobilurin G, produced by B. lutea.^[7][8] A related material, hydroxystrobilurin D, with an additional hydroxyl group attached to the methyl of the main chain is produced by Mycena sanguinolenta.^[7]

Strobilurin E is produced by Crepidotus fulvotomentosus^[8] and Favolaschia spp.^[7]

Strobilurin F2 is produced by B. lutea.^[6]

Strobilurin H is produced by B. lutea.^[7] The natural product with a phenolic hydroxy group in place of the aromatic methoxy group of strobilurin H is called strobilurin F1 and is found in C. anomala^[8] and Agaricus spp.^[6]

Strobilurin X is produced by O. mucida.^[7][8]

The oudemansins are closely related to the strobilurins and are also quinone outside inhibitors.^[7]

Oudemansin A with R₁ = R₂ = H was first described in 1979, after being isolated from mycelial fermentations of the basidiomycete fungus Oudemansiella mucida.^[9] Later it was found in cultures of the basidiomycete fungi Mycena polygramma and Xerula melanotricha. The latter fungus also produces oudemansin B, with R₁ = MeO and R₂ = Cl. Oudemansin X, with R₁ = H and R₂ = MeO was isolated from Oudemansiella radicata.^[6]

The discovery of the strobilurin class of fungicides led to the development of a group of commercial fungicides used in agriculture. Examples are shown below.^[5]

• 
  Azoxystrobin
• 
  Trifloxystrobin
• 
  Kresoxim methyl
• 
  Pyraclostrobin

• Plant pathology

• Resistance to strobilurins in the southern USA, archived from the original on 2019-09-08, retrieved 2019-09-08
• Agricultural mycocides for the 21st century: strobilurins, archived from the original on 2019-09-08, retrieved 2019-09-08, from: David Moore, Geoffrey D. Robson, Anthony P. J. Trinci, 21st Century Guidebook to Fungi, 2nd edition.