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TNP1 - Wikipedia

From Wikipedia, the free encyclopedia

TNP1

Identifiers

Aliases

TNP1, TP1, transition protein 1

External IDs

OMIM: 190231; MGI: 98784; HomoloGene: 136517; GeneCards: TNP1; OMA:TNP1 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q35	Start	216,859,458 bp^[1]
Band	2q35	End	216,860,064 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 C3\|1 36.94 cM	Start	73,054,233 bp^[2]
Band	1 C3\|1 36.94 cM	End	73,055,068 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

right testis

left testis

testicle

cartilage tissue

tail of epididymis

cerebellar vermis

caput epididymis

paraflocculus of cerebellum

corpus epididymis

Top expressed in

seminiferous tubule

spermatid

perirhinal cortex

spermatocyte

entorhinal cortex

interventricular septum

cardiac muscle tissue of left ventricle

plantaris muscle

extensor digitorum longus muscle

choroid plexus of fourth ventricle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding protein binding
Cellular component	male germ cell nucleus nucleosome chromosome nucleus
Biological process	multicellular organism development single strand break repair flagellated sperm motility chromatin remodeling spermatid nucleus differentiation cell differentiation spermatid nucleus elongation nucleosome disassembly negative regulation of transcription, DNA-templated sexual reproduction spermatogenesis spermatid development positive regulation of protein processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7141


21958

Ensembl


ENSG00000118245


ENSMUSG00000026182

UniProt


P09430


P10856

RefSeq (mRNA)


NM_003284


NM_009407

RefSeq (protein)


NP_003275


NP_033433

Location (UCSC)

Chr 2: 216.86 – 216.86 Mb

Chr 1: 73.05 – 73.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118245 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026182 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W (Jan 1991). "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2". Genomics. 8 (2): 324–30. doi:10.1016/0888-7543(90)90289-7. PMID 2249851.
^ "Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)".

Meistrich ML, Mohapatra B, Shirley CR, Zhao M (2004). "Roles of transition nuclear proteins in spermiogenesis". Chromosoma. 111 (8): 483–8. doi:10.1007/s00412-002-0227-z. PMID 12743712. S2CID 28866607.
Chirat F, Martinage A, Briand G, et al. (1991). "Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants" (PDF). Eur. J. Biochem. 198 (1): 13–20. doi:10.1111/j.1432-1033.1991.tb15980.x. PMID 2040274.
Baskaran R, Rao MR (1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J. Biol. Chem. 265 (34): 21039–47. doi:10.1016/S0021-9258(17)45324-5. PMID 2250010.
Kleene KC, Borzorgzadeh A, Flynn JF, et al. (1988). "Nucleotide sequence of a cDNA clone encoding mouse transition protein 1". Biochim. Biophys. Acta. 950 (2): 215–20. doi:10.1016/0167-4781(88)90013-9. PMID 3382664.
Luerssen H, Hoyer-Fender S, Engel W (1988). "The nucleotide sequence of human transition protein 1 cDNA". Nucleic Acids Res. 16 (15): 7723. doi:10.1093/nar/16.15.7723. PMC 338445. PMID 3412903.
Akama K, Kojima S, Nakano M, et al. (1994). "The amino acid sequence and phosphorylation sites of a boar transition protein 1". Biochem. Mol. Biol. Int. 32 (2): 349–57. PMID 8019440.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
Yu YE, Zhang Y, Unni E, et al. (2000). "Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4683–8. Bibcode:2000PNAS...97.4683Y. doi:10.1073/pnas.97.9.4683. PMC 18293. PMID 10781074.
Siffroi JP, Alfonsi MF, Dadoune JP (2001). "Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids". Italian Journal of Anatomy and Embryology = Archivio Italiano di Anatomia ed Embriologia. 103 (4 Suppl 1): 65–74. PMID 11315969.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.

Structures of the cell nucleus / nuclear protein

Envelope (membrane)/
nuclear lamina

Pore complex:
Nucleoporin
- NUP35
- NUP37
- NUP43
- NUP50
- NUP54
- NUP62
- NUP85
- NUP88
- NUP93
- NUP98
- NUP107
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
AAAS

Nucleolus

Cajal (coiled) body
- SMN
- GEMIN2
- GEMIN4
- GEMIN5
- GEMIN6
- GEMIN7
- DDX20
- COIL
Perinucleolar compartment
- PTBP1
- CUGBP1
TCOF
ATXN7

Other

Chromatin Dot (PML body) Paraspeckle
SMC protein:	Cohesin SMC1A SMC1B SMC3 Condensin NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 SMC2 SMC4 DNA repair SMC5 SMC6
Transition nuclear protein:	TNP1 TNP2
Nuclear matrix (Nucleoskeleton) Nucleoplasm (Nucleosol)
LITAF
see also transcription factors and intracellular receptors

see also nucleus diseases

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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References

Further reading