Villoglandular adenocarcinoma of the cervix

From Wikipedia, the free encyclopedia

Villoglandular adenocarcinoma of the cervix
Other names	Villoglandular papillary adenocarcinoma, papillary villoglandular adenocarcinoma, well-differentiated villoglandular adenocarcinoma (VGA)

Micrograph of a villoglandular adenocarcinoma the cervix. H&E stain.
Specialty	Pathology, gynecology

Villoglandular adenocarcinoma of the cervix is a rare type of cervical cancer that, in relation to other cervical cancers, is typically found in younger women and has a better prognosis.^[1]

A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the endometrium.^[2]

Signs and symptoms

The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.^{[citation needed]}

Cause

This section is empty. You can help by adding to it. (August 2017)

Diagnosis

The diagnosis is based on tissue examination, e.g. biopsy.

The name of the lesion describes it microscopic appearance. It has nipple-like structures with fibrovascular cores (papillae) that are long in relation to their width (villus-like), which are covered with a glandular pseudostratified columnar epithelium.^{[citation needed]}

Very low magnification
Intermediate magnification
Very high magnification

Treatment

The treatment is dependent on the stage. As the prognosis of this tumour is usually good, fertility sparing approaches (conization, cervicectomy) may be viable treatment options.^{[citation needed]}

References

^ Korach, J.; Machtinger, R.; Perri, T.; Vicus, D.; Segal, J.; Fridman, E.; Ben-Baruch, G. (2009). "Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge". Acta Obstet Gynecol Scand. 88 (3): 355–8. doi:10.1080/00016340902730359. PMID 19172445. S2CID 5835426.
^ Zaino, RJ.; Kurman, RJ.; Brunetto, VL.; Morrow, CP.; Bentley, RC.; Cappellari, JO.; Bitterman, P. (Nov 1998). "Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study". Am J Surg Pathol. 22 (11): 1379–85. doi:10.1097/00000478-199811000-00008. PMID 9808130.

Tumors of the female urogenital system

Adnexa

Ovaries

Glandular and epithelial/
surface epithelial-
stromal tumor

CMS:	Ovarian serous cystadenoma Mucinous cystadenoma Cystadenocarcinoma Papillary serous cystadenocarcinoma Krukenberg tumor
Endometrioid tumor Ovarian clear-cell carcinoma Brenner tumour

Sex cord–gonadal stromal

Germ cell

Fibroma

Meigs' syndrome

Fallopian tube

Adenomatoid tumor

Uterus

Myometrium	Uterine fibroids/leiomyoma Leiomyosarcoma Adenomyoma
Endometrium	Endometrioid tumor Uterine papillary serous carcinoma Endometrial intraepithelial neoplasia Uterine clear-cell carcinoma
Cervix	Cervical intraepithelial neoplasia Clear-cell carcinoma SCC Glassy-cell carcinoma Villoglandular adenocarcinoma
Placenta	Choriocarcinoma Gestational trophoblastic disease
General	Uterine sarcoma Mixed Müllerian tumor

Vagina

Vulva

Categories:

Hidden categories:

Signs and symptoms

Cause

Diagnosis

Treatment

See also

References